↔ Factors II, V IX and protein C |
↑ Concentration of factors VII, VIII, X and vWF and pronounced increases in fibrinogen |
↓ Protein S |
Plasminogen activator inhibitor type 1 levels are ↑ five-fold |
PAI-2 produced by the placenta ↑ dramatically during third trimester |
Markers of the thrombin generation such as prothrombin F1 and 2 and thrombin-antithrombin complexes are also increased |
Do not return to baseline until more than 8 weeks postpartum, and begin at conception |