RT Journal Article SR Electronic T1 ERS School Course Cystic Fibrosis JF Breathe JO Breathe FD European Respiratory Society SP 321 OP 331 DO 10.1183/18106838.0104.321 VO 1 IS 4 A1 A. Bush A1 S. Elborn A1 I. Götz YR 2005 UL http://breathe.ersjournals.com/content/1/4/321.abstract AB Educational aimsTo identify patients with advanced and rapidly progressive lung disease.To discuss how to best optimise standard therapies.To understand the different approaches appropriate to patients who have and have not decided that lung transplantation is an option.To detail innovative strategies which may be worth attempting if conventional means failure.Summary More than 90% of CF patients will eventually die of advanced lung disease, despite everything that has been attempted. This article will discuss strategies that can be adopted when a patient is doing badly.