RT Journal Article SR Electronic T1 Severe Paediatric Asthma Collaborative in Europe (SPACE): protocol for a European registry JF Breathe JO Breathe FD European Respiratory Society SP 93 OP 98 DO 10.1183/20734735.002018 VO 14 IS 2 A1 Norrice M. Liu A1 Wim van Aalderen A1 Karin C.L. Carlsen A1 Courtney Coleman A1 James D. Chalmers A1 Steve Cunningham A1 Ricardo M. Fernandes A1 Louise J. Fleming A1 Monika Gappa A1 Bülent Karadag A1 Fabio Midulla A1 Marielle W.H. Pijnenburg A1 Niels W. Rutjes A1 Franca Rusconi A1 Jonathan Grigg YR 2018 UL http://breathe.ersjournals.com/content/14/2/93.abstract AB The development of new asthma biologics and receptor blockers for the treatment of paediatric severe asthma raises challenges. It is unclear whether there are sufficient children in Europe to recruit into randomised placebo-controlled trials to establish efficacy and safety in this age group.In February 2016, the European Respiratory Society funded a clinical research collaboration entitled “Severe Paediatric Asthma Collaborative in Europe” (SPACE). We now report the SPACE protocol for a prospective pan-European observational study of paediatric severe asthma. Inclusion criteria are: 1) age 6–17 years, 2) severe asthma managed at a specialised centre for ≥6 months, 3)clinical and spirometry evidence of asthma, and 4) reaching a pre-defined treatment threshold. The exclusion criterion is the presence of conditions which mimic asthma symptoms. Eligible children will be prospectively recruited into a registry, recording demographics, comorbidities, quality of life, family history, neonatal history, smoking history, asthma background, investigations, and treatment. Follow-up will provide longitudinal data on asthma control and treatment changes.The SPACE registry, by identifying well-phenotyped children eligible for clinical trials, and the amount of overlap in eligibility criteria, will inform the design of European trials in paediatric severe asthma, and facilitate observational research where data from single centres are limited.An ERS funded clinical research collaboration has developed a protocol for a paediatric severe asthma study to support asthma biologics trials http://ow.ly/YQkW30j32xJ