| Renal failure | Cisplatin and mitomycin are contra-indicated. Consider carboplatin (prescribed according to renal clearance). |
| Liver diseases | Cisplatin-based with drugs nonmetabolised by the liver. |
| Bone marrow | Chemotherapy with reduced dosages and with active haematological support. |
| Cardiac failure | Cisplatin, taxans and ifosfamide are contra-indicated. Consider nonplatinum-based chemotherapy. |
| Polyneuropathy | Cisplatin, vinca-alcaloids and taxans are contra-indicated. Consider regimens with ifosfamide, gemcitabine, carboplatin or/and etoposide or TKI. |
| Hypoacousia | Platinum derivatives are contra-indicated. Consider nonplatinum-based chemotherapy. |