| Author (Year) | Drugs | Patients n | Response rate % | Median survival months | 1-year survival rate % | p-value |
| Elvis (1999) | VNR | 76 | 19.7 | 6.5 | 32 | 0.03 |
| BSC | 85 | 19.7 | 4.9 | 14 | ||
| Frasci (2000) | VNR | 60 | 22 | 7 | 13 | <0.01 |
| Gem + VNR | 60 | 15 | 4.5 | 30 | ||
| Gridelli (2003) | VNR | 21 | 8.5 | 42 | ns | |
| Gem | 700 | 16 | 6.5 | 28 | ||
| Gem + VNR | 18.1 | 7.4 | 34 | |||
| Kudoh (2006) | VNR | 182 | 9.9 | 9.9 | NR | ns |
| Doc | 182 | 22.7 | 14 | NR | ||
| Tsukada (2007) | Doc Carbo + Doc | 63 | ||||
| Quoix (2011) | VNR or Gem | 226 | 10 | 6.2 | 25.4 | 0.0004 |
| Carbo + weekly Pacli | 225 | 27 | 10.3 | 44.5 |