Table 1 Paraneoplastic syndromes associated with lung cancer [5, 6]
SyndromePatients affected %Causative protein or antibody
Hyponatraemia/SIADH15Arginine vasopressin or atrial natriuretic peptide
Ectopic corticotropin syndrome2–5Corticotropin
Lambert–Eaton myasthenic syndrome3Voltage-gated calcium channel antibody
Acromegaly<1GHRH
Gynaecomastia<1
Hypercoagulability<1
Thrombocytosis<1
Encephalomyelitis/subacute sensory neuropathy<1Anti-Hu, amphiphysin, CV2
Cancer-associated retinopathy<1Anti-recoverin
Dermatomyositis<1
Acanthosis palmaris, erythema gyratum repens<1
Nephrotic syndrome<1
  • SIADH: syndrome of inadequate antidiuretic hormone; GHRH: growth hormone-releasing hormone.