Original studyAbnormalities of skeletal muscle in patients with chronic heart failure
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Cited by (331)
Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities
2022, Biomedicine and PharmacotherapyCitation Excerpt :These data suggest that type I fibers exhibit a very active aerobic metabolic profile, whereas type II fibers prefer to utilize glycolysis and glycogenolysis for energy with less oxygen dependence [52,53]. In HF patients, skeletal muscle is characterized by fiber atrophy, decreased fiber capillary density in type I and IIa fibers, reduced percentage of type I fiber, and increased type IIb/X fibers ratio [15,47], along with altered oxidase expression and activity[16]. Specifically, citrate synthase (CS) and succinate dehydrogenase (SDH) activities are reduced in the myocyte mitochondria of HF patients [16,26,54,55] and correlate with the maximum oxygen uptake[56].
Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator
2022, Nitric Oxide - Biology and ChemistryThe Role of Adipose Triglyceride Lipase and Cytosolic Lipolysis in Cardiac Function and Heart Failure
2020, Cell Reports MedicineCitation Excerpt :Twenty years ago, Tikunov and colleagues provided indirect evidence of stimulated lipolysis and FA oxidation in the diaphragmatic muscle by showing a significantly increased activity of β-hydroxyacyl-coenzyme A dehydrogenase in patients with advanced HFrEF (mean EF: 18% ± 8%).81 In contrast, other groups demonstrated excess intracellular lipid accumulation in quadriceps biopsies from HFrEF patients and increased intramyocellular lipid content in tibialis anterior muscles studied by 1H-magnetic resonance spectroscopy, indicative of decreased TAG turnover.82,83 Robust evidence exists for an enhanced, non-cardiac systemic lipolysis during HF development (Figure 2), with most studies performed in HFrEF patients.
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D.P. Lipkin was supported by a Squibb Research Fellowship Grant.