Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months of age☆,☆☆,★
Section snippets
METHODS
The healthy term infants enrolled in the CHIME study were born at 38 to 42 weeks’ gestation. All were appropriate for gestational age, were normal at delivery, were discharged with the mother, and were ≤30 days old at enrollment. The exclusion criteria included any acute illness and a family history of sudden infant death syndrome. Written informed consent was obtained for each infant, and the Institutional Review Board at each site approved the study.
Among the 214 healthy term infants enrolled
RESULTS
The 64 infants in this study were compared with the 150 healthy term infants not included (Table).
Group characteristics Study group (≥50 h/mo for ≥3 mo) (n = 64) Comparison (insufficient monitor use) (n = 150) Maternal characteristics Age* 31.8 (5.7) 28.8 (6.1) Education* 15.9 (2.9) 14.4 (2.7) Race/ethnic group* % White 64.1 47.3 % Black 3.1 21.6 % Hispanic 7.8 8.1 %
DISCUSSION
The features of the CHIME monitor enabled recording of 35,127 3-minute observations unaffected by monitor alarms or other systematic perturbations and have yielded new insights into baseline and acute decreases in SpO2. Infants with ≥1 low baseline SpO2 were more likely to have ≥1 acute decrease in SpO2. The acute decreases improve with age and are primarily associated with periodic breathing; periodic breathing is more common in nonprone sleeping positions. Because the periodic breathing,
References (19)
- et al.
Comparison of pulse oximeters in healthy sleeping infants
Respir Med
(1989) - et al.
Saturation by pulse oximetry: comparison of the results obtained by instruments of different brands
J Pediatr
(1993) Sudden Infant Death Syndrome
- et al.
Oxygen saturation and breathing patterns in infancy. I. Full term infants in the second month of life
Arch Dis Child
(1991) - et al.
Arterial oxygen saturation in healthy term infants
Eur J Pediatr
(1996) - et al.
Transcutaneous oxygen saturation in sleeping infants: prone and supine
Arch Dis Child
(1990) - et al.
Home documented monitoring of cardiorespiratory pattern and oxygen saturation in healthy infants
Pediatr Res
(1996) - et al.
Agreement among raters in assessment of physiologic waveforms recorded by a cardiorespiratory monitor for home use
Pediatr Res
(1998) - et al.
Hypoxic events in spontaneously rebreathing premature infants: etiologic basis
Pediatr Res
(1997)
Cited by (114)
Mechanical environment influences muscle activity during infant rolling
2024, Human Movement ScienceMuscle activation and coordinated movements of infant rolling
2024, Journal of BiomechanicsSleep from Infancy Through Adolescence
2023, Sleep Medicine ClinicsDuration and Consequences of Periodic Breathing in Infants Born Preterm Before and After Hospital Discharge
2023, Journal of PediatricsSudden Infant Death Syndrome
2020, Encyclopedia of Infant and Early Childhood DevelopmentOxygen in Acute Bronchiolitis
2018, Clinical Pediatric Emergency MedicineCitation Excerpt :Most providers understand that the evaluation of the infant with bronchiolitis in the ED is limited and that we are likely catching episodes of hypoxia that are occurring normally outside of the care setting. In fact, some oxygen desaturations are likely normal (healthy infants have desaturations during sleep).24 Some studies have shown lower mortality when oxygen saturations are maintained above 90% in premature infants,25 and neurodevelopmental delays with mild desaturations in children with congenital heart disease,26 or those living at high altitude.27
- ☆
The CHIME study is supported by National Institute of Child Health and Human Development HD: 29067, 29071, 28971, 29073, 29060, 29056, and 34625.
- ☆☆
Reprint requests: Carl E. Hunt, MD, Department of Pediatrics, Medical College of Ohio, Toledo, OH 43614-2598.
- ★
0022-3476/99/$8.00 + 0 9/21/101362