Transplantation infectionAspergillus infections after lung transplantation: clinical differences in type of transplant and implications for management
Section snippets
Methods
Cases of Aspergillus infections in lung transplant recipients were identified by a Medline search through December 2000. Search terms included “aspergillosis,” “fungal infections” and “lung transplant.” Additional cases were identified by review of the bibliographies of the search articles. The studies included had to provide a definition of invasive aspergillosis to distinguish colonization from infection. Reports were limited to those published in or translated into English. Cases reported in
Epidemiology and demographic characteristics
A total of 159 cases of Aspergillus infections were identified in 40 published reports.1, 2, 3, 4, 5, 6, 7, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43 Of these, 87 were individually detailed cases, and 72 were summarized in reports containing 2 to 14 cases. The type of lung transplantation was reported in 66 patients. Overall, 51.5% (34 of 66) of the patients with Aspergillus infections were single lung
Discussion
Although previous reports have alluded to a higher incidence of Aspergillus infections in single lung transplant recipients,37, 42 our study has documented the unique characteristics and an overall greater impact of Aspergillus infections after single lung transplantation. Single lung transplant recipients were significantly older, more likely to have chronic obstructive pulmonary disease as an indication for lung transplantation or have developed Aspergillus infections later after
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2022, Journal of Infection and ChemotherapyCitation Excerpt :The results showed that there was a significant difference between the IA group and the control group in the proportion of patients with a history of interstitial pneumonia and steroid use before transplantation: 67% of patients in the IA group had a history of interstitial pneumonia and were using steroids prior to transplantation, compared to 22% in the control group. IA remains a major cause of death after lung transplantation [14]. However, the optimal prophylactic strategy remains undefined [7].