Clinical investigation: congestive heart failureAssociation between chronic heart failure and inhaled β-2-adrenoceptor agonists☆
Section snippets
Methods
The data for this study were collected as part of the Ambulatory Care Quality Improvement Project (ACQUIP). ACQUIP was a multicenter, randomized, clinical trial designed to test whether monitoring patients' self-reported health and provision of regular reports to primary care clinicians improves clinical outcomes and patients' satisfaction. Details of the clinical trial have been described previously.19 The current analysis included those subjects who were enrolled at the inception of the
Discussion
The primary objective of this study was to examine the association between inhaled β-agonists and the risk of hospital admission for CHF. We found that subjects who had a previous diagnosis of CHF had a dose-dependent increase in risk for hospitalization, whereas those without this history did not. The increase in risk among patients with existing CHF was independent of history of COPD, steroid use, β-blocker use, ACE inhibitor use, myocardial ischemia, and cardiovascular risk factors. Although
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Funding for this project was provided through the Department of Veterans Affairs and Health Services Research and Development, SDR96-002, Ambulatory Care Quality Improvement Project (ACQUIP). Dr. Au was funded by a Department of Veterans Affairs Career Development Award.
The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veteran Affairs.