Original articleGeneral thoracicLocalized Organizing Pneumonia: Report of 21 Cases
Section snippets
Patients and Methods
This was a retrospective study, and, as individual patients were not identified, our ethics committee waived the requirement to obtain patient consent in the study. We reviewed the pathologic registries of the San Raffaele Scientific Institute, Milan, and Carlo Poma Hospital, Mantua, covering a 3-year period (August 2001 through October 2004) to identify all the patients with localized pulmonary abnormalities (nodules or masses) that had been shown to consist of BOOP at pathologic examination.
Results
We identified 25 patients with pathologic and radiologic evidence of localized organizing pneumonia. Four patients were excluded from the study because localized organizing pneumonia was an incidental finding occurring in the immediate vicinity of other processes (tumors, bronchiectases, and pulmonary sequestration) for which the resection had been performed. The remaining 21 patients were included in the study. There were 15 men and 6 women with a mean age of 63 years (range, 46 to 81 years).
Comment
Although rare, localized organizing pneumonia is an extremely interesting entity for the thoracic surgeon, who may have to differentiate it from a primary or metastatic lung tumor. Described for the first time in 1989 by Cordier and colleagues [13], localized organizing pneumonia has subsequently been analyzed as a distinct form of BOOP in only a few studies [9, 10, 11, 14, 15]. Unlike typical BOOP, its clinical, radiologic, and evolutive characteristics are therefore not entirely clear.
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Cicatricial variant of cryptogenic organizing pneumonia
2017, Human PathologyCitation Excerpt :Cryptogenic organizing pneumonia (COP, aka bronchiolitis obliterans with organizing pneumonia) was initially described by Epler et al [1] and Davison et al [2] as a distinct pattern of lung injury that needed to be separated clinically and histologically from idiopathic usual interstitial pneumonia (UIP). In contrast to UIP, COP is a subacute illness affecting middle-aged men and women that is sensitive to high-dose steroid therapy in an overwhelming majority of cases (>80%) [3-15]. Radiographically, COP is characterized by migratory ground glass opacities without honeycomb change, traction bronchiectasis, or other roentgenographic manifestations of irreversible lung injury.
Cryptogenic organizing pneumonia
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