Normal development of the lung and premature birth

…, KO McKay, PP van Asperen, H Selvadurai… - Paediatric respiratory …, 2010 - Elsevier
The following review focuses on the normal development of the lung from conception to birth.
The defined periods of lung development–Embryonic, Pseudoglandular, Canalicular, …

Bioenergetic provision of energy for muscular activity

GD Wells, H Selvadurai, I Tein - Paediatric respiratory reviews, 2009 - Elsevier
… Water (H 2 O) hydrolyzes the unstable chemical bonds of the phosphate groups of the
ATP molecule, yielding an inorganic phosphate molecule (Pi) and adenosine diphosphate (ADP). …

Childhood interstitial lung disease: a systematic review

…, Y Zurynski, D Fitzgerald, H Selvadurai… - Pediatric …, 2015 - Wiley Online Library
Objectives Childhood interstitial lung disease (chILD) is a group of rare chronic and complex
disorders of variable pathology. There has been no systematic review of published chILD …

[HTML][HTML] The PHANTASTICA gene encodes a MYB transcription factor involved in growth and dorsoventrality of lateral organs in Antirrhinum

R Waites, HRN Selvadurai, IR Oliver, A Hudson - Cell, 1998 - cell.com
… floral meristems at about the floritypic stage (E) was compared in serial sections to that of
FLO (F) and PLE (G) and characterized in wild-type flowers at a later stage in development (H). …

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

…, NI Park, FJ Coutinho, H Whetstone, HJ Selvadurai… - Nature, 2017 - nature.com
Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive
tumorigenesis. However, the origin of intratumoural functional heterogeneity between glioblastoma …

Efficacy and safety of lumacaftor and ivacaftor in patients aged 6–11 years with cystic fibrosis homozygous for F508del-CFTR: a randomised, placebo-controlled …

…, P Reix, A Malfroot, S Bui, H Selvadurai… - The lancet Respiratory …, 2017 - thelancet.com
Background Lumacaftor and ivacaftor combination treatment showed efficacy in patients
aged 12 years or older with cystic fibrosis homozygous for F508del-cystic fibrosis …

Randomized controlled study of in‐hospital exercise training programs in children with cystic fibrosis

HC Selvadurai, CJ Blimkie, N Meyers… - Pediatric …, 2002 - Wiley Online Library
The aim of this study was to compare aerobic and resistance training in children with cystic
fibrosis (CF) admitted to hospital with an intercurrent pulmonary infection with a control group. …

[HTML][HTML] Quiescent Sox2+ cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma

RJ Vanner, M Remke, M Gallo, HJ Selvadurai… - Cancer cell, 2014 - cell.com
Functional heterogeneity within tumors presents a significant therapeutic challenge. Here
we show that quiescent, therapy-resistant Sox2 + cells propagate sonic hedgehog subgroup …

[PDF][PDF] ASCL1 reorganizes chromatin to direct neuronal fate and suppress tumorigenicity of glioblastoma stem cells

…, RJ Vanner, E Ling, P Prinos, L Lee, H Selvadurai… - Cell stem cell, 2017 - cell.com
Glioblastomas exhibit a hierarchical cellular organization, suggesting that they are driven by
neoplastic stem cells that retain partial yet abnormal differentiation potential. Here, we show …

Ivacaftor treatment of cystic fibrosis in children aged 12 to< 24 months and with a CFTR gating mutation (ARRIVAL): a phase 3 single-arm study

…, E Gaillard, P McNalley, H Selvadurai… - The lancet respiratory …, 2018 - thelancet.com
… Ivacaftor doses were based on weight: children who weighed 7 to <14 kg received 50 mg
every 12 h and those who weighed ≥14 to <25 kg received 75 mg every 12 h. The drug was …