Zircon (ZrSiO4) is a common accessory mineral in nature, occurring in a wide variety of
sedimentary, igneous, and metamorphic rocks. Known to incorporate an assortment of minor and …

Ribonucleotide reductase (EC 1.17. 4.1; RR) plays a central role in the de novo synthesis of
deoxyribonucleotides required for DNA replication and repair (1, 2) and there is a strong …

Leading articles activity in vivo during infection have yet to be demonstrated directly. However,
mutants with defects in quorum sensing do exhibit reduced virulence12–14 and it is also …

Background Cytomegalovirus (CMV) disease in immunocompromised patients correlates
with a deficiency of CD8+ cytotoxic T lymphocytes specific for CMV. We evaluated the safety …

Background Aggregated α-synuclein plays an important role in the pathogenesis of Parkinson’s
disease. The monoclonal antibody prasinezumab, directed at aggregated α-synuclein, is …

A prospective one-year study ofcommunity pneumonia was conducted in Nottingham. 236 of
251 episodes of pneumonia (defined as an acute lower respiratory tract infection, for which …

Background & Aims: Gain-of-function trypsin mutations cause acute pancreatitis and chronic
pancreatitis. Loss of trypsin inhibitor function may have similar effects. We investigated the …

Antimicrobial resistance is threatening the management of infections such as pneumonia,
tuberculosis, malaria, and AIDS. In the past, resistance could be handled by development of …

The blood–brain barrier and a blood–cerebrospinal-fluid (CSF) barrier function together to
isolate the brain from circulating drugs, toxins, and xenobiotics. The blood–CSF drug-…

… The dehydration of schoepite was described by Finch et al. (1992, 1998) (see below),
who … This is consistent with a recent structure refinement for billietite (Finch et al. in prep.). …