User profiles for S. Orfanos

Stylianos Orfanos

Professor of Critical Care, National and Kapodistrian University of Athens
Verified email at med.uoa.gr
Cited by 21536

Pulmonary endothelium in acute lung injury: from basic science to the critically ill

SE Orfanos, I Mavrommati, I Korovesi… - Applied Physiology in …, 2012 - Springer
… TNF-a and IL-1 share a number of biological properties and markedly amplify each other’s
biological actions. They act on EC mainly by inducing a functional program that promotes …

Immunothrombosis in acute respiratory distress syndrome: cross talks between inflammation and coagulation

F Frantzeskaki, A Armaganidis, SE Orfanos - Respiration, 2017 - karger.com
… Interaction of thrombin with PAR-1, 3, and 4 on platelet’s membrane leads to further platelet
activation and recruitment. Moreover, the activation of PAR-2 by the TF:fVIIa complex results …

Endothelial pathomechanisms in acute lung injury

…, A Kotanidou, JD Catravas, SE Orfanos - Vascular pharmacology, 2008 - Elsevier
Acute lung injury (ALI) and its most severe extreme the acute respiratory distress syndrome (ARDS)
refer to increased-permeability pulmonary edema caused by a variety of pulmonary …

Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators

SE Orfanos, A Kotanidou, C Glynos… - Critical care …, 2007 - journals.lww.com
… Spearman rank correlation coefficients (r s ) were calculated to describe the … s = −0.280, p
< .05) but did not correlate with chest roentgenogram score (r s = 0.269), lung injury score (r s

Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre …

…, G Pitsiou, S Orfanos, M D'Alto, S Ghio… - The Lancet …, 2021 - thelancet.com
Background Riociguat and phosphodiesterase-5 inhibitors (PDE5i), approved for the
treatment of pulmonary arterial hypertension (PAH), act on the same pathway via different …

Neutrophil CD64 expression and serum IL-8: sensitive early markers of severity and outcome in sepsis

…, A Armaganidis, C Roussos, SE Orfanos… - Cytokine, 2006 - Elsevier
… The aim of the present study was to investigate which biomarker/s reliably assess severity
and mortality early in the sepsis process. In 47 critically-ill patients within the 24 h of septic …

[HTML][HTML] Endothelial damage in acute respiratory distress syndrome

…, A Kotanidou, I Dimopoulou, SE Orfanos - International journal of …, 2020 - mdpi.com
… Similarly, plasma TM is increased in infants with respiratory distress syndrome, especially
in those treated with mechanical ventilation [204], while elevated plasma soluble (s)TM levels …

The endothelium in acute lung injury/acute respiratory distress syndrome

NA Maniatis, SE Orfanos - Current opinion in critical care, 2008 - journals.lww.com
… of topical administration of APC in a model of direct ALI via PMN-independent pathway(s). …
69• Kinniry P, Pick J, Stephens S, et al. KL4-surfactant prevents hyperoxic and LPS-induced …

[HTML][HTML] Validation of the new Sepsis-3 definitions: proposal for improvement in early risk identification

…, A Ioakeimidou, A Kotanidou, SE Orfanos… - Clinical Microbiology …, 2017 - Elsevier
… Consenting comprised the analysis of clinical, laboratory and therapeutic variables
associated with patient’s outcomes. This allowed retrospective classification of patients using the …

[HTML][HTML] Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis

…, G Dimopoulos, A Pantazi, SE Orfanos… - BMC medicine, 2017 - Springer
… Ferritin is increased at levels often exceeding 4000 ng/ml in autoinflammatory syndromes
like Still’s disease and acute gouty arthritis [20] that are mediated through excess production of …