User profiles for S. Orfanos
Stylianos OrfanosProfessor of Critical Care, National and Kapodistrian University of Athens Verified email at med.uoa.gr Cited by 21536 |
Pulmonary endothelium in acute lung injury: from basic science to the critically ill
SE Orfanos, I Mavrommati, I Korovesi… - Applied Physiology in …, 2012 - Springer
… TNF-a and IL-1 share a number of biological properties and markedly amplify each other’s
biological actions. They act on EC mainly by inducing a functional program that promotes …
biological actions. They act on EC mainly by inducing a functional program that promotes …
Immunothrombosis in acute respiratory distress syndrome: cross talks between inflammation and coagulation
F Frantzeskaki, A Armaganidis, SE Orfanos - Respiration, 2017 - karger.com
… Interaction of thrombin with PAR-1, 3, and 4 on platelet’s membrane leads to further platelet
activation and recruitment. Moreover, the activation of PAR-2 by the TF:fVIIa complex results …
activation and recruitment. Moreover, the activation of PAR-2 by the TF:fVIIa complex results …
Endothelial pathomechanisms in acute lung injury
…, A Kotanidou, JD Catravas, SE Orfanos - Vascular pharmacology, 2008 - Elsevier
Acute lung injury (ALI) and its most severe extreme the acute respiratory distress syndrome (ARDS)
refer to increased-permeability pulmonary edema caused by a variety of pulmonary …
refer to increased-permeability pulmonary edema caused by a variety of pulmonary …
Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators
SE Orfanos, A Kotanidou, C Glynos… - Critical care …, 2007 - journals.lww.com
… Spearman rank correlation coefficients (r s ) were calculated to describe the … s = −0.280, p
< .05) but did not correlate with chest roentgenogram score (r s = 0.269), lung injury score (r s …
< .05) but did not correlate with chest roentgenogram score (r s = 0.269), lung injury score (r s …
Switching to riociguat versus maintenance therapy with phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension (REPLACE): a multicentre …
Background Riociguat and phosphodiesterase-5 inhibitors (PDE5i), approved for the
treatment of pulmonary arterial hypertension (PAH), act on the same pathway via different …
treatment of pulmonary arterial hypertension (PAH), act on the same pathway via different …
Neutrophil CD64 expression and serum IL-8: sensitive early markers of severity and outcome in sepsis
… The aim of the present study was to investigate which biomarker/s reliably assess severity
and mortality early in the sepsis process. In 47 critically-ill patients within the 24 h of septic …
and mortality early in the sepsis process. In 47 critically-ill patients within the 24 h of septic …
[HTML][HTML] Endothelial damage in acute respiratory distress syndrome
… Similarly, plasma TM is increased in infants with respiratory distress syndrome, especially
in those treated with mechanical ventilation [204], while elevated plasma soluble (s)TM levels …
in those treated with mechanical ventilation [204], while elevated plasma soluble (s)TM levels …
The endothelium in acute lung injury/acute respiratory distress syndrome
NA Maniatis, SE Orfanos - Current opinion in critical care, 2008 - journals.lww.com
… of topical administration of APC in a model of direct ALI via PMN-independent pathway(s). …
69• Kinniry P, Pick J, Stephens S, et al. KL4-surfactant prevents hyperoxic and LPS-induced …
69• Kinniry P, Pick J, Stephens S, et al. KL4-surfactant prevents hyperoxic and LPS-induced …
[HTML][HTML] Validation of the new Sepsis-3 definitions: proposal for improvement in early risk identification
…, A Ioakeimidou, A Kotanidou, SE Orfanos… - Clinical Microbiology …, 2017 - Elsevier
… Consenting comprised the analysis of clinical, laboratory and therapeutic variables
associated with patient’s outcomes. This allowed retrospective classification of patients using the …
associated with patient’s outcomes. This allowed retrospective classification of patients using the …
[HTML][HTML] Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis
…, G Dimopoulos, A Pantazi, SE Orfanos… - BMC medicine, 2017 - Springer
… Ferritin is increased at levels often exceeding 4000 ng/ml in autoinflammatory syndromes
like Still’s disease and acute gouty arthritis [20] that are mediated through excess production of …
like Still’s disease and acute gouty arthritis [20] that are mediated through excess production of …