Medical diagnosis and phenotyping increasingly incorporate information from complex
biological samples. This has promoted the development and clinical application of non-invasive …

Exhaled breath contains thousands of volatile organic compounds that reflect the metabolic
process occurring in the host both locally in the airways and systemically. They also arise …

Breath tests cover the fraction of nitric oxide in expired gas (F ENO ), volatile organic compounds
(VOCs), variables in exhaled breath condensate (EBC) and other measurements. For …

Diagnostic strategies currently used for pneumonia are time-consuming, lack accuracy and
suffer from large inter-observer variability. Exhaled breath contains thousands of volatile …

Purpose Mechanical power (MP) may unify variables known to be related to development of
ventilator-induced lung injury. The aim of this study is to examine the association between …

Background Severe COVID-19 is characterised by inflammation and coagulation in the
presence of complement system activation. We aimed to explore the potential benefit and safety …

Rationale We hypothesised that patients with acute respiratory distress syndrome (ARDS)
can be clustered based on concentrations of plasma biomarkers and that the thereby …

Background Mortality rates are high among hospitalized patients with COVID-19, especially
in those intubated on the ICU. Insight in pathways associated with unfavourable outcome …

Background Co-infection is frequently seen in critically ill patients with influenza, although
the exact rate is unknown. We determined the rate of co-infection, the risk factors and the …

Purpose Severe community-acquired pneumonia (sCAP) is associated with high morbidity
and mortality, and whilst European and non-European guidelines are available for community…