Figures
- Figure 1
The SPACE registry data collection platform.
Tables
- Table 1
Inclusion and exclusion criteria for SPACE registry participants
Inclusion criteria Age 6–17 years Diagnosis confirmed, evaluated and managed at a specialised centre for ≥6 months Symptoms Wheeze heard by trained healthcare professional OR Self-reported wheeze in the past 12 months Spirometry evidence of asthma Bronchial obstruction with bronchodilator reversibility ≥12% OR Bronchial provocation test with ≥10% fall in FEV1 Treatment High-dose inhaled corticosteroids (table 2) for ≥6 months + long-acting β-agonist/leukotriene modifier OR Systemic corticosteroids for ≥25% of the past 12 months Exclusion criteria Symptoms are primarily due to the following conditions, which might mimic asthma Allergic bronchopulmonary aspergillosis Bronchiolitis obliterans Cystic fibrosis Primary ciliary dyskinesia Significant bronchiectasis (not related to asthma) Severe immunodeficiency/immunosuppression Central airway obstruction, or compression Congenital airway malformation (e.g. vascular ring) Foreign body Tracheobronchomalacia Interstitial lung disease Lobectomy Other pulmonary surgery Carcinoid or other tumour Congenital heart disease Connective tissue disease Neuromuscular diseases FEV1: forced expiratory volume in 1 s.
- Table 2
Definition of high-dose inhaled corticosteroids for inclusion criteria
Inhaled corticosteroid Dose μg Inhaler type Beclomethasone ≥800 DPI, CFC MDI ≥320 HFA MDI Budesonide ≥800 MDI, DPI Ciclesonide ≥160 HFA MDI Fluticasone ≥500 HFA MDI, DPI Fluticasone furoate ≥200 DPI Fluticasone propionate ≥400 DPI ≥500 HFA Mometasone ≥500 DPI Triamcinolone ≥1200 DPI: dry powder inhaler; MDI: metered-dose inhaler; CFC: chlorofluorocarbon; HFA: hydrofluoroalkane.
- Table 3
Participating specialised centres across Europe
Participating centre Country Marien Hospital Germany Anna Meyer Children’s University Hospital Italy Sapienza University of Rome Italy Emma Childrens Hospital AMC The Netherlands Erasmus MC–Sophia Children’s Hospital The Netherlands Oslo University Hospital Norway Hospital de Santa Maria Portugal Marmara University Faculty of Medicine Pendik Hospital Turkey Royal Brompton Hospital UK Royal Hospital for Sick Children, Edinburgh UK Royal London Hospital UK
Vol 14 Issue 2
Table of Contents
Severe Paediatric Asthma Collaborative in Europe (SPACE): protocol for a European registry
