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A disease with many faces

Nídia Caires, Sara Campos Silva, Maria Inês Moreira, Rita Gerardo, Alexandra Borba, João Santos Silva, Rita Barata, Eugénia Pinto, João Cardoso
Breathe 2019 15: e77-e83; DOI: 10.1183/20734735.0161-2019
Nídia Caires
1Pulmonology Dept, Hospital Santa Marta, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
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  • For correspondence: nidiacaires@gmail.com
Sara Campos Silva
1Pulmonology Dept, Hospital Santa Marta, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
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Maria Inês Moreira
1Pulmonology Dept, Hospital Santa Marta, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
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Rita Gerardo
1Pulmonology Dept, Hospital Santa Marta, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
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Alexandra Borba
1Pulmonology Dept, Hospital Santa Marta, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
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João Santos Silva
2Cardiothoracic Surgery Dept, Hospital Santa Marta, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
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Rita Barata
2Cardiothoracic Surgery Dept, Hospital Santa Marta, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
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Eugénia Pinto
3Pathology Dept, Hospital São José, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
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João Cardoso
1Pulmonology Dept, Hospital Santa Marta, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
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    Figure 1

    Posteroanterior chest radiograph.

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    Figure 2

    Chest CT shows a) multiple and bilateral micronodules with random distribution, traction bronchiectasis especially in upper lobes; and b) pleural thickening. c) View of coronal section.

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    Figure 3

    Bronchofibroscopy, showing no endobronchial abnormalities.

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    Figure 4

    Microscopic examination of lung and pleural biopsies with haematoxylin and eosin stain. a) Non-necrotising epithelioid granulomas with multinucleated giant cells (40× magnification) in b) interstitial and subpleural location (10× magnification). c) Fibrotic areas and diffuse inflammatory lymphoplasmacytic infiltrate with granulomas in parietal pleura (10× magnification). No neoplastic tissue. Special stains for fungus and mycobacteria were negative (not shown).

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    Figure 5

    Posteroanterior chest radiograph, showing mild bilateral nodular opacities.

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Vol 15 Issue 2 Table of Contents
Breathe: 15 (2)
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A disease with many faces
Nídia Caires, Sara Campos Silva, Maria Inês Moreira, Rita Gerardo, Alexandra Borba, João Santos Silva, Rita Barata, Eugénia Pinto, João Cardoso
Breathe Jun 2019, 15 (2) e77-e83; DOI: 10.1183/20734735.0161-2019

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A disease with many faces
Nídia Caires, Sara Campos Silva, Maria Inês Moreira, Rita Gerardo, Alexandra Borba, João Santos Silva, Rita Barata, Eugénia Pinto, João Cardoso
Breathe Jun 2019, 15 (2) e77-e83; DOI: 10.1183/20734735.0161-2019
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