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Protracted bacterial bronchitis is a precursor for bronchiectasis in children: myth or maxim?

Anne B. Chang, Julie M. Marchant
Breathe 2019 15: 167-170; DOI: 10.1183/20734735.0178-2019
Anne B. Chang
1Dept of Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, Australia
2Center for Children's Health Research, Queensland University of Technology, Brisbane, Australia
3Child Health Division, Menzies School of Health Research, Darwin, Australia
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  • For correspondence: anne.chang@menzies.edu.au
Julie M. Marchant
1Dept of Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, Australia
2Center for Children's Health Research, Queensland University of Technology, Brisbane, Australia
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    Figure 1

    Using the pathobiological model, PBB, chronic suppurative lung disease (CSLD) and radiographically confirmed bronchiectasis probably represent different ends of a spectrum with similar underlying mechanisms of airway neutrophilia, endobronchial bacterial infection and impaired mucociliary clearance. Untreated it is likely some (but not all) children with PBB will progress to develop CSLD and some will ultimately develop bronchiectasis, initially reversible and subsequently irreversible if left to progress. There is a degree of overlap between each of the entities. Reproduced from [11] with permission from the publisher.

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Vol 15 Issue 3 Table of Contents
Breathe: 15 (3)
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Protracted bacterial bronchitis is a precursor for bronchiectasis in children: myth or maxim?
Anne B. Chang, Julie M. Marchant
Breathe Sep 2019, 15 (3) 167-170; DOI: 10.1183/20734735.0178-2019

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Protracted bacterial bronchitis is a precursor for bronchiectasis in children: myth or maxim?
Anne B. Chang, Julie M. Marchant
Breathe Sep 2019, 15 (3) 167-170; DOI: 10.1183/20734735.0178-2019
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  • Article
    • Abstract
    • Introduction
    • Data from days gone by
    • What is PBB and is it real?
    • Biological plausibility
    • Data linking PBB to bronchiectasis
    • Summary
    • Footnotes
    • References
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Subjects

  • CF and non-CF bronchiectasis
  • Paediatric pulmonology
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