Figures
- Figure 1
Forest plot of the RR of the cumulative incidence of lung cancer (estimates >1 represent overdiagnosis). The meta-analysis includes all trials, regardless of bias assessment. Trials are listed alphabetically. M-H: Mantel-Haenszel; df: degrees of freedom.
- Figure 2
Forest plot of estimates of overdiagnosis defined as the fraction of screen-detected lung cancers that represent overdiagnosis. Meta-analysis includes all trials, regardless of bias assessment. Trials are listed alphabetically. IV: inverse variance; df: degrees of freedom.
- Figure 3
Forest plot of the RR of the cumulative incidence of lung cancer (estimates >1 represent overdiagnosis). The meta-analysis only includes low risk of bias trials. Trials are listed alphabetically. M-H: Mantel-Haenszel; df: degrees of freedom.
- Figure 4
Forest plot of estimates of overdiagnosis defined as the fraction of screen-detected lung cancers that represent overdiagnosis. The meta-analysis only includes low risk of bias trials. Trials are listed alphabetically. IV: inverse variance; df: degrees of freedom.
Tables
- Table 1
Characteristics of included studies
Trial name Population characteristics Intervention (screening interval months/rounds) Total subjects (intervention/control arm subjects) Control Follow-up time after last screen years Participation rate Contamination rate DLCST Men and women aged 50–70 years, smokers and former smokers ≥20 pack-years
Former smokers must have quit <10 years priorLDCT (12/5) 4104 (2052/2052) Usual care 5 95.5% 20.3% ITALUNG Men and women aged 55–69 years, smokers and former smokers ≥20 pack-years in past 10 years LDCT (12/4) 3206 (1613/1593) Usual care 5 81% Not reported LUSI Men and woman aged 50–69 years, smokers and former smokers (cessation <10 years) with ≥25 years of smoking ≥15 cigarettes a day or 30 years of smoking 10 cigarettes per day LDCT (12/5) 4052 (2029/2023) Usual care 3 >90% 8.7% MILD Men and women aged 49–75 years, current or former (cessation <10 years) ≥20 pack-years LDCT (12 or 24/6 or 3)
Median duration of screening was 6.2 years4099 (2376/1723) Usual care The follow-up since last screening round is unclear 95.1% in the biennial and 96.1% in the annual LDCT group 1.2% NELSON Men aged 50–74 years, current or former smokers (who had quit ≤10 years ago) who had smoked >15 cigarettes a day for >25 years or >10 cigarettes a day for >30 years LDCT (12, 24, 30/4) 13 195 (6583/6612) Usual care 4.5 85.8% in total (lowest at round 4 with 67.4% and highest at round 1 with 95.8%) Not reported
Supplementary Material
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Table S1. Characteristics of identified studies EDU-0013-2020.tableS1
