Disorders of surfactant protein metabolism | SFTPB, STFPC, ABCA3 and TTF1 mutations |
GM-CSF receptor gene mutations | α- and β-chain mutations |
Other genetic disorders | MARS, STING, COPA and GATA2 mutations |
Metabolic disease | Lysinuric protein intolerance, Niemann–Pick disease |
Associated with immune deficiency | |
Congenital | SCID, ADA deficiency |
Acquired | HIV, leukaemia |
Associated with connective tissue disease | Idiopathic juvenile chronic arthritis |
Miscellaneous | Congenital heart disease |
Diseases seen in adults | |
Exclusively in adults | Macrophage blockade, lymphoma |
Mainly in adults | Autoimmune |