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A double-edged sword

Martijn Vandebotermet, Frederik Staels, Simone Giovannozzi, Michel Delforge, Thomas Tousseyn, Thomas Steelandt, Anniek Corveleyn, Isabelle Meyts, Johan Maertens, Jonas Yserbyt, Rik Schrijvers
Breathe 2020 16: 200017; DOI: 10.1183/20734735.0017-2020
Martijn Vandebotermet
1Respiratory Medicine, University Hospitals Leuven, Leuven, Belgium
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  • For correspondence: martijn.vandebotermet@uzleuven.be
Frederik Staels
2Dept of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium
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Simone Giovannozzi
2Dept of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium
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Michel Delforge
3Dept of Haematology, University Hospitals Leuven, Leuven, Belgium
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Thomas Tousseyn
4Dept of Pathology, University Hospitals Leuven, Leuven, Belgium
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Thomas Steelandt
4Dept of Pathology, University Hospitals Leuven, Leuven, Belgium
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Anniek Corveleyn
5Center for Human Genetics, University of Leuven, Leuven, Belgium
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Isabelle Meyts
6Depts of Pediatrics, and Microbiology and Immunology, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium
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Johan Maertens
3Dept of Haematology, University Hospitals Leuven, Leuven, Belgium
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Jonas Yserbyt
1Respiratory Medicine, University Hospitals Leuven, Leuven, Belgium
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Rik Schrijvers
2Dept of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium
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    Figure 1

    a) Posteroanterior and b) lateral chest radiography showing a diffuse reticulonodular pattern with slight apicobasal gradient and normal cardiac silhouette.

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    Figure 2

    a) Contrast-enhanced chest CT parenchymal window. b) High-resolution CT during inspiration.

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    Figure 3

    FDG-PET, maximum intensity projection. Diffuse supra- and infra-diaphragmatic distribution of FDG-avid adenopathies with increased captation of the spleen. Diffuse FDG-avid lesions spread in the lung parenchyma.

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    Figure 4

    a) Overview of lymph node excision biopsy showing follicular hyperplasia (arrows) and granulomas (arrowheads). b) Detail of multiple, large secondary reactive germ centres of variable shape and size (arrows). Scale bar=100μm. c) Detail of the sinus of the lymph node with a sharply delineated granuloma consisting of multinucleated giant cells and histiocytes.

  • Figure 5
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    Figure 5

    a) High-resolution computed tomography in inspiration during follow-up (interval: 9-years). b) Follow-up CT with disappearance of ground-glass opacities with progression towards a reticular interstitial pattern.

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Vol 16 Issue 3 Table of Contents
Breathe: 16 (3)
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A double-edged sword
Martijn Vandebotermet, Frederik Staels, Simone Giovannozzi, Michel Delforge, Thomas Tousseyn, Thomas Steelandt, Anniek Corveleyn, Isabelle Meyts, Johan Maertens, Jonas Yserbyt, Rik Schrijvers
Breathe Sep 2020, 16 (3) 200017; DOI: 10.1183/20734735.0017-2020

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A double-edged sword
Martijn Vandebotermet, Frederik Staels, Simone Giovannozzi, Michel Delforge, Thomas Tousseyn, Thomas Steelandt, Anniek Corveleyn, Isabelle Meyts, Johan Maertens, Jonas Yserbyt, Rik Schrijvers
Breathe Sep 2020, 16 (3) 200017; DOI: 10.1183/20734735.0017-2020
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