Tables
- Table 1
Studies assessing lung function in children with IBD
Lung function technique Reference Study population Finding Body plethysmography
Spirometry[14] 25 CD and 25 UC versus 39 controls No difference [57] 12 CD and 18 UC versus 32 controls No difference [48] 30 CD and 18 UC versus 108 controls MEF50, MEF25 reduced in CD [56] 52 CD and 48 UC versus 50 controls FEV1, FVC reduced
15 restrictive
19 obstructiveDLCO [14] 25 CD and 25 UC versus 39 controls No difference [57] 12 CD and 18 UC versus 32 controls No difference [48] 30 CD and 18 UC versus 108 controls DLCO reduced [56] 52 CD and 48 UC versus 50 controls DLCO reduced Methacholine bronchoprovocation challenge [14] 25 CD and 25 UC versus 39 controls 12% of IBD patients with BHR FENO [48] 30 CD and 18 UC versus 108 controls No difference [57] 12 CD and 18 UC versus 32 controls No difference [14] 25 CD and 25 UC versus 39 controls FENO higher in UC [55] 30 CD and 30 asthma versus 20 controls No correlation between FENO and CD activity Lung clearance index [57] 12 CD and 18 UC versus 32 controls No difference Exhaled breath condensate [54] 22 CD and 25 UC versus 37 controls IL-6, TNF-α, IL-1β significantly higher in IBD [55] 30 CD and 30 asthma versus 20 controls pH lower in IBD and asthma
8-isoprostane differed between groupsMEF50/25: maximum expiratory flow at 50/25% of FVC; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; BHR: bronchial hyperresponsiveness; FENO: fractional exhaled nitric oxide.
Vol 17 Issue 1
Table of Contents
Inflammatory bowel disease and the lung in paediatric patients
