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It's not all about inhaled treatment: challenges with oral therapy in paediatric respiratory medicine

Anneka Sareen, Manisha Ramphul, Jayesh Mahendra Bhatt
Breathe 2021 17: 210005; DOI: 10.1183/20734735.0005-2021
Anneka Sareen
1Pharmacy Dept, Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK
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Manisha Ramphul
2Paediatric Respiratory Medicine, Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK
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  • ORCID record for Manisha Ramphul
Jayesh Mahendra Bhatt
2Paediatric Respiratory Medicine, Nottingham Children's Hospital, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, UK
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  • ORCID record for Jayesh Mahendra Bhatt
  • For correspondence: jayesh.bhatt@nuh.nhs.uk
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    Figure 1

    Treatments taken each day (including oral, subcutaneous and nebulised medication and medicines/feeds via the gastrostomy).

Tables

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  • Table 1

    Algorithm on acceptable medicine forms for different age groups

    Liquid#Conventional or minitabletMulti-particulateOrodispersible tabletChewable tablet
    Neonates<0.5 mL volume
    Neutral taste
    2 mm minitablet acceptableXXX
    Infants<2.5 mL volume
    Neutral taste
    <3 mm tablet
    Up to 3 tablets per dose
    Neutral taste<6.5 mm tablet
    Neutral taste
    X
    Children aged 2–5 years<2.5 mL volume
    Neutral taste
    Up to 10 minitablets acceptable
    <4 mm tablet
    Up to 3 tablets per dose
    Neutral taste<9.5 mm tablet
    Neutral taste
    <9.5 mm tablet
    Neutral taste
    Children aged 6–12 years<10 mL volume
    Neutral taste
    <7 mm tablet
    Up to 3 tablets per dose
    Neutral taste<9.5 mm tablet
    Neutral taste
    <14.7 mm tablet
    Neutral taste

    #: including dispersible tablet or granules for reconstitution. Information from [19].

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      Supplementary table S1 EDU-0005-2021.supplement

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    It's not all about inhaled treatment: challenges with oral therapy in paediatric respiratory medicine
    Anneka Sareen, Manisha Ramphul, Jayesh Mahendra Bhatt
    Breathe Mar 2021, 17 (1) 210005; DOI: 10.1183/20734735.0005-2021

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    It's not all about inhaled treatment: challenges with oral therapy in paediatric respiratory medicine
    Anneka Sareen, Manisha Ramphul, Jayesh Mahendra Bhatt
    Breathe Mar 2021, 17 (1) 210005; DOI: 10.1183/20734735.0005-2021
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    • Article
      • Abstract
      • Abstract
      • Case vignette
      • Introduction
      • Types of formulations
      • Non-interchangeable oral formulations
      • Issues around palatability, swallowing of medication or lack of suitable formulations
      • Factors influencing starting to take tablets
      • Alternatives to tablets: liquid formulations
      • Polypharmacy
      • Cardiac side-effects of respiratory drugs
      • Diet and oral medication
      • What can healthcare professionals do to support patients with taking oral medication?
      • What can parents do to maximise compliance with oral medication?
      • Conclusion
      • Supplementary material
      • Footnotes
      • References
    • Figures & Data
    • Info & Metrics
    • PDF

    Subjects

    • Paediatric pulmonology
    • Pulmonary pharmacology and therapeutics
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