Figures
- Figure 1
Overview of the most common pulmonary pathology findings observed in post-mortem patients affected by various degrees of severity of COVID-19. See the text for more details and explanations.
- Figure 2
Factors contributing to lung transfer (or diffusing) capacity for carbon monoxide ( TLCO or DLCO). See the text for more details and explanations.
- Figure 3
Algorithm allowing physiologists and clinicians to unravel mechanisms of a decreased TLCO (or DLCO). If TLCO (or DLCO) is reduced, the next step is to check whether the VA is preserved or reduced. If VA is diminished, the next step is to check whether the VA/TLC ratio is low (<80%) due to ventilation maldistribution secondary to an obstructive ventilatory defect or is preserved (≥80%) due to restrictive ventilatory defect, associated or not with impaired pulmonary gas exchange. If VA is preserved, please follow the arrows in the algorithm to get some explanations and to see whether the KCO is reduced and if there are pulmonary gas exchange anomalies associated with this. “Coronavirus diseases” appears in red, as potential mechanisms explaining the TLCO (or DLCO) anomalies observed in coronavirus diseases such as COVID-19 (caused by SARS-CoV-2), severe acute respiratory syndrome (SARS; caused by SARS-CoV-1) and Middle East respiratory syndrome (MERS; caused by MERS-CoV) are yet not fully understood. See the text for more details and explanations. IPF: idiopathic pulmonary fibrosis; ILD: interstitial lung disease.
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- Article
- Abstract
- Abstract
- Introduction
- Physiology and pathophysiology of abnormal pulmonary function variables as observed in COVID-19 survivors
- Abnormal respiratory function in COVID-19 patients
- Potential hypotheses on altered TLCO or DLCO in COVID-19 survivors
- Specific features of respiratory dysfunction in COVID-19 compared with other viral pneumonias (SARS, MERS, and influenza A H1N1)
- Future directions, perspectives and conclusions
- Footnotes
- References
- Figures & Data
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