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Can vitamin D3 supplementation reduce the time to severe asthma exacerbations in children with asthma?

Idan Bokobza, Nour El Hadi, Andrew Bush, Heidi Makrinioti
Breathe 2021 17: 210071; DOI: 10.1183/20734735.0071-2021
Idan Bokobza
1West Middlesex University Hospital, Chelsea, and Westminster Foundation Trust, London, UK
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  • For correspondence: idanbokobza@nhs.net
Nour El Hadi
1West Middlesex University Hospital, Chelsea, and Westminster Foundation Trust, London, UK
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Andrew Bush
2Imperial Centre for Paediatrics and Child Health, Imperial College, London, UK
3National Heart and Lung Institute, Imperial College, London, UK
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Heidi Makrinioti
1West Middlesex University Hospital, Chelsea, and Westminster Foundation Trust, London, UK
2Imperial Centre for Paediatrics and Child Health, Imperial College, London, UK
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    Figure 1

    Actions of vitamin D on B-cells, T-cells and activated mast cells in the context of an allergen/virus-induced exacerbation of asthma. Th: T-helper cell; Treg: regulatory T-cell; Ig: immunoglobulin.

Tables

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    Randomised controlled trials of vitamin D3 supplementation in preschool and school-age children with asthma

    StudyStudy typeStudy populationAge, yearsBaseline 25(OH)D, nmol·L−1Oral dose of vitamin D3 (intervention arm)Outcome
    Urashima et al. [17]Randomised controlled trialSchool-age children with asthma9.5 (2.1; 6.0–15.0)Not determined1200 IU·day−1Significant preventive effect against influenza A LRTIs
    Majak et al. [18]Randomised controlled trial with a cohort designSchool-age children with asthma10.9 (3.3; 6.0–17.0)88.9 (38.2; 31.5–184.7)500 IU·day−1Reduced the number of asthma exacerbations triggered by acute respiratory tract infection during 6 months of follow-up
    Tachimoto et al. [19]Randomised controlled trial with a cohort designSchool-age children with asthma9.9 (2.3; 6.0–15.0)74.9 (24.6; 20.0–187.2)800 IU·day−1Improved ACT at 6 months of follow-up
    Jensen et al. [20]Randomised controlled trial with a cohort designPreschool children with recurrent wheeze2.9 (1.1; 1.6–5.5)64.2 (14.0; 42·0–87·0)100 000 IU bolus plus 400 IU·day−1No effect on use of oral corticosteroids during 6 months of follow-up
    Kerley et al. [21]Randomised controlled trial with a cohort designSchool-age children with asthma8.6 (2.8; 5.0–15.0)54.4 (17.4; 26.0–92.0)2000 IU·day−1No significant difference in asthma control during 4 months of follow-up
    Jat et al. [15]Randomised controlled trial with a cohort designPreschool and school-age children with asthma8.1 (2.3; 4.0–12.0)18.6 (4.1; 21.7–32.9)1000 IU·day−1No significant difference in asthma control and in the number of asthma exacerbations during 9 months of follow-up

    Data are presented as median (minimum; interquartile range), unless stated otherwise. 25(OH)D: 25-hydroxyvitamin D; LRTI: lower respiratory tract infection; ACT: asthma control test.

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    Can vitamin D3 supplementation reduce the time to severe asthma exacerbations in children with asthma?
    Idan Bokobza, Nour El Hadi, Andrew Bush, Heidi Makrinioti
    Breathe Sep 2021, 17 (3) 210071; DOI: 10.1183/20734735.0071-2021

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    Can vitamin D3 supplementation reduce the time to severe asthma exacerbations in children with asthma?
    Idan Bokobza, Nour El Hadi, Andrew Bush, Heidi Makrinioti
    Breathe Sep 2021, 17 (3) 210071; DOI: 10.1183/20734735.0071-2021
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