Figures
- Figure 1
Actions of vitamin D on B-cells, T-cells and activated mast cells in the context of an allergen/virus-induced exacerbation of asthma. Th: T-helper cell; Treg: regulatory T-cell; Ig: immunoglobulin.
Tables
- Table 1
Randomised controlled trials of vitamin D3 supplementation in preschool and school-age children with asthma
Study Study type Study population Age, years Baseline 25(OH)D, nmol·L−1 Oral dose of vitamin D3 (intervention arm) Outcome Urashima et al. [17] Randomised controlled trial School-age children with asthma 9.5 (2.1; 6.0–15.0) Not determined 1200 IU·day−1 Significant preventive effect against influenza A LRTIs Majak et al. [18] Randomised controlled trial with a cohort design School-age children with asthma 10.9 (3.3; 6.0–17.0) 88.9 (38.2; 31.5–184.7) 500 IU·day−1 Reduced the number of asthma exacerbations triggered by acute respiratory tract infection during 6 months of follow-up Tachimoto et al. [19] Randomised controlled trial with a cohort design School-age children with asthma 9.9 (2.3; 6.0–15.0) 74.9 (24.6; 20.0–187.2) 800 IU·day−1 Improved ACT at 6 months of follow-up Jensen et al. [20] Randomised controlled trial with a cohort design Preschool children with recurrent wheeze 2.9 (1.1; 1.6–5.5) 64.2 (14.0; 42·0–87·0) 100 000 IU bolus plus 400 IU·day−1 No effect on use of oral corticosteroids during 6 months of follow-up Kerley et al. [21] Randomised controlled trial with a cohort design School-age children with asthma 8.6 (2.8; 5.0–15.0) 54.4 (17.4; 26.0–92.0) 2000 IU·day−1 No significant difference in asthma control during 4 months of follow-up Jat et al. [15] Randomised controlled trial with a cohort design Preschool and school-age children with asthma 8.1 (2.3; 4.0–12.0) 18.6 (4.1; 21.7–32.9) 1000 IU·day−1 No significant difference in asthma control and in the number of asthma exacerbations during 9 months of follow-up Data are presented as median (minimum; interquartile range), unless stated otherwise. 25(OH)D: 25-hydroxyvitamin D; LRTI: lower respiratory tract infection; ACT: asthma control test.
Vol 17 Issue 3
Table of Contents
Can vitamin D3 supplementation reduce the time to severe asthma exacerbations in children with asthma?
