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Reply to: Magnesium sulphate intravenously reduces tachycardia side-effects of β2-agonists

Colin Powell, Gokul Erumbala, Sabu Anzar, Amjad Tonbari, Ramadan Salem
Breathe 2022 18: 220024; DOI: 10.1183/20734735.0024-2022
Colin Powell
1Pediatric Emergency Dept, Sidra Medicine, Doha, Qatar
2Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK
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  • ORCID record for Colin Powell
  • For correspondence: cpowell@sidra.org
Gokul Erumbala
1Pediatric Emergency Dept, Sidra Medicine, Doha, Qatar
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Sabu Anzar
1Pediatric Emergency Dept, Sidra Medicine, Doha, Qatar
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Amjad Tonbari
1Pediatric Emergency Dept, Sidra Medicine, Doha, Qatar
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Ramadan Salem
1Pediatric Emergency Dept, Sidra Medicine, Doha, Qatar
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Abstract

Intravenous magnesium sulphate reduces β2-agonist induced tachycardia https://bit.ly/3pPnGKl

Reply to: W.F.S. Sellers and M.F.M. James:

We thank W.F.S. Sellers and M.F.M. James for their correspondence in response to our review on the use of intravenous magnesium sulphate in acute asthma in childhood [1] and welcome their comments. Salbutamol induced tachycardia and palpitations are a concern in younger children when treated with large doses of salbutamol [2]. Emphasising the effect that magnesium has on reducing this tachycardia is important. We were aware of the lack of evidence for the 20-min infusion rate but did not mention it in the paper. Recognising that it is safe and may have a greater effect if delivered at a greater speed will be useful for further development of randomised controlled acute asthma in childhood studies. This illustrates how important it is to share experience across specialties.

Footnotes

  • Conflict of interest: The authors have nothing to disclose.

  • Received February 27, 2022.
  • Accepted March 2, 2022.
  • Copyright ©ERS 2022
http://creativecommons.org/licenses/by-nc/4.0/

Breathe articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

References

  1. ↵
    1. Erumbala G,
    2. Anzar S,
    3. Tonbari A, et al.
    Stating the obvious: intravenous magnesium sulphate should be the first parenteral bronchodilator in paediatric asthma exacerbations unresponsive to first-line therapy. Breathe 2021; 17: 210113. doi:10.1183/20734735.0113-2021
    OpenUrl
  2. ↵
    1. Starkey ES,
    2. Mulla H,
    3. Sammons HM, et al.
    Intravenous salbutamol for childhood asthma: evidence-based medicine? Arch Dis Child 2014; 99: 873–877. doi:10.1136/archdischild-2013-304467
    OpenUrlAbstract/FREE Full Text
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Reply to: Magnesium sulphate intravenously reduces tachycardia side-effects of β2-agonists
Colin Powell, Gokul Erumbala, Sabu Anzar, Amjad Tonbari, Ramadan Salem
Breathe Mar 2022, 18 (1) 220024; DOI: 10.1183/20734735.0024-2022

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Reply to: Magnesium sulphate intravenously reduces tachycardia side-effects of β2-agonists
Colin Powell, Gokul Erumbala, Sabu Anzar, Amjad Tonbari, Ramadan Salem
Breathe Mar 2022, 18 (1) 220024; DOI: 10.1183/20734735.0024-2022
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