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Beyond antibiotics: recent developments in the diagnosis and management of nontuberculous mycobacterial infection

Laura E. Gleeson, Grant Waterer
Breathe 2022 18: 210171; DOI: 10.1183/20734735.0171-2021
Laura E. Gleeson
1Dept of Clinical Medicine, Trinity College School of Medicine, Dublin, Ireland
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Grant Waterer
2School of Medicine, University of Western Australia, Perth, Australia
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  • For correspondence: grant.waterer@uwa.edu.au
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Tables

  • TABLE 1

    Recent and ongoing clinical trials of new and emerging therapies for NTM

    AgentCompanyMechanism of actionTarget populationPhaseClinicalTrials.gov identifierStatus
    ALISInsmed Inc.Inhaled amikacinTreatment refractory MACIIINCT02344004Completed
    ALISInsmed Inc.Inhaled amikacinTreatment naïve MACIIINCT04677569Recruiting
    ALISInsmed Inc.Inhaled amikacinTreatment refractory M. abscessusIINCT03038178Completed
    BedaquilineJanssen Pharmaceutical K.K.Inhibition of energy metabolismTreatment refractory MACII/IIINCT04630145Recruiting
    ClofazimineInhibition of DNA replicationMACIINCT02968212Recruiting
    OmadacyclineParatek Pharmaceuticals Inc.Inhibition of protein synthesis (tetracycline)M. abscessusIINCT04922554Recruiting
    LinezolidSiam Pharmaceutical Ltd.Inhibition of protein synthesisNTM pulmonary diseaseIVNCT03220074Recruiting
    Inhaled nitric oxideMycobacterial killingNTM pulmonary diseaseNCT03748992Completed
    Inhaled nitric oxideMallinckrodt PharmaceuticalsMycobacterial killingNTM pulmonary diseaseNCT03473314Completed
    Inhaled nitric oxideMallinckrodt PharmaceuticalsMycobacterial killingNTM pulmonary diseaseNCT03331445Terminated
    Inhaled nitric oxideBeyond Air Inc.Mycobacterial killingM. abscessusIINCT03208764Completed
    Inhaled nitric oxideBeyond Air Inc.Mycobacterial killingTreatment refractory NTMNCT04685720Recruiting
    IFN-γ/GM-CSFImmunomodulationMAC pulmonary diseaseINCT00111397Completed
    GM-CSFSavara Inc.ImmunomodulationTreatment refractory NTMIINCT03421743Completed
    GM-CSFSavara Inc.ImmunomodulationCystic fibrosis NTM infectionIINCT03597347Terminated
    IL-7RevimmuneImmunomodulationTreatment refractory NTMIINCT04154826Recruiting
    i.v. GalliumDisruption of iron metabolismCystic fibrosis NTM infectionIbNCT04294043Recruiting

    ALIS: amikacin liposome inhalation suspension; MAC: Mycobacterium avium complex; IFN-γ: interferon gamma; GM-CSF: granulocyte–macrophage colony-stimulating factor; IL: interleukin.

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    Beyond antibiotics: recent developments in the diagnosis and management of nontuberculous mycobacterial infection
    Laura E. Gleeson, Grant Waterer
    Breathe Jun 2022, 18 (2) 210171; DOI: 10.1183/20734735.0171-2021

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    Beyond antibiotics: recent developments in the diagnosis and management of nontuberculous mycobacterial infection
    Laura E. Gleeson, Grant Waterer
    Breathe Jun 2022, 18 (2) 210171; DOI: 10.1183/20734735.0171-2021
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