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CPAP for secondary cardiovascular prevention in obstructive sleep apnoea patients: not only one moon, but many stars

Sébastien Baillieul, Neeraj M. Shah, Rivindi Dharmasena, Sophia Schiza, Dries Testelmans, Athanasia Pataka
Breathe 2022 18: 220148; DOI: 10.1183/20734735.0148-2022
Sébastien Baillieul
1Grenoble Alpes University, HP2 Laboratory, INSERM U1300 and Grenoble Alpes University Hospital, Grenoble, France
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  • ORCID record for Sébastien Baillieul
  • For correspondence: SBaillieul@chu-grenoble.fr
Neeraj M. Shah
2Lane Fox Respiratory Research Centre, Guy's and St. Thomas’ NHS Foundation Trust, London, UK
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Rivindi Dharmasena
3Westmead Hospital, Western Sydney Health, Westmead, Australia
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Sophia Schiza
4Sleep Disorders Centre, Dept of Respiratory Medicine, Medical School, University of Crete, Heraklion, Greece
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Dries Testelmans
5KU Leuven – University of Leuven, University Hospitals Leuven, Department of Respiratory diseases, Leuven, Belgium
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Athanasia Pataka
6Aristotle University Thessaloniki and Respiratory Failure Unit, Aristotle University Thessaloniki, G. Papanikolaou Hospital Exohi, Thessaloniki, Greece
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Tables

  • TABLE 1

    General characteristics of the participants included in the randomised controlled trials assessing the effects of continuous positive airway pressure (CPAP) treatment on cardiovascular morbimortality

    SAVE study [12]RICCADSA study [13]ISAACC study [15]
    Inclusion criteriaModerate-severe OSA (ODI ≥12 events·h−1)Moderate-severe OSA (AHI ≥15 events·h−1)Moderate-severe OSA (AHI ≥15 events·h−1)
    Coronary artery disease or cerebrovascular diseaseCoronary artery diseaseAcute coronary syndrome
    Exclusion criteriaSevere daytime sleepiness (ESS >15/24)Excessive daytime sleepiness (ESS ≥10/24)Excessive daytime sleepiness (ESS >10/24)
    Age, years616660
    Men, %818584
    ESS7.45.55.2
    AHI, events·h−1312936
    Number of events, n (%)CPAP: 229 (17%)CPAP: 22 (18%)CPAP: 98 (16%)
    Usual care: 207 (15%)Usual care: 27 (22%)Usual care: 108 (17%)
    CPAP use, mean±sd, h per night3.3±2.3Not stated2.8±2.7

    Age, ESS, AHI are presented as the mean values for the study cohort. AHI: apnoea–hypopnoea index; ESS: Epworth sleepiness scale; ODI: oxygen desaturation index; OSA: obstructive sleep apnoea.

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    CPAP for secondary cardiovascular prevention in obstructive sleep apnoea patients: not only one moon, but many stars
    Sébastien Baillieul, Neeraj M. Shah, Rivindi Dharmasena, Sophia Schiza, Dries Testelmans, Athanasia Pataka
    Breathe Sep 2022, 18 (3) 220148; DOI: 10.1183/20734735.0148-2022

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    CPAP for secondary cardiovascular prevention in obstructive sleep apnoea patients: not only one moon, but many stars
    Sébastien Baillieul, Neeraj M. Shah, Rivindi Dharmasena, Sophia Schiza, Dries Testelmans, Athanasia Pataka
    Breathe Sep 2022, 18 (3) 220148; DOI: 10.1183/20734735.0148-2022
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