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Non-CPAP therapy for obstructive sleep apnoea

Johan Verbraecken, Marijke Dieltjens, Sara Op de Beeck, Anneclaire Vroegop, Marc Braem, Olivier Vanderveken, Winfried Randerath
Breathe 2022 18: 220164; DOI: 10.1183/20734735.0164-2022
Johan Verbraecken
1Department of Pulmonary Medicine, Antwerp University Hospital, Edegem (Antwerp), Belgium
2Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital, Edegem, Belgium
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  • ORCID record for Johan Verbraecken
  • For correspondence: johan.verbraecken@uza.be
Marijke Dieltjens
3Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium
4Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium
5Special Dentistry Care, Antwerp University Hospital, Edegem, Belgium
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Sara Op de Beeck
3Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium
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  • ORCID record for Sara Op de Beeck
Anneclaire Vroegop
2Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital, Edegem, Belgium
3Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium
4Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium
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  • ORCID record for Anneclaire Vroegop
Marc Braem
3Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium
5Special Dentistry Care, Antwerp University Hospital, Edegem, Belgium
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Olivier Vanderveken
2Multidisciplinary Sleep Disorders Centre, Antwerp University Hospital, Edegem, Belgium
3Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium
4Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Edegem, Belgium
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Winfried Randerath
6Bethanien Hospital, Clinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Institute of Pneumology at the University of Cologne, Solingen, Germany
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    FIGURE 1

    Current treatment modalities in obstructive sleep apnoea (OSA). Dashed arrows: mandibular advancement device (MAD) therapy or upper airway surgery indicated in patients who do not tolerate continuous positive airway pressure (CPAP). MMA: maxillomandibular advancement; rEDS: residual excessive daytime sleepiness. #: in selected patients (drug-induced sleep endoscopy); ¶: if position dependent.

Tables

  • Figures
  • TABLE 1

    Potential side-effects during mandibular advancement device treatment

    TransientPersistent
    Discomfort or pain in the mandibular joint complexOccasional damage to teeth and prosthetic restorations
    Stiff masticatory musclesTooth shifting with undesirable occlusion changes
    Dry mouthPeriodontal problems
    Excessive salivation
    Tooth sensitivity
    Gum irritation
  • TABLE 2

    Current upper airway and maxillofacial surgeries for obstructive sleep apnoea (OSA)

    Intervention siteMain proceduresMain indications
    NoseSeptoplasty
    Turbinoplasty
    For subjects with persistent nasal obstruction, mainly to improve feasibility of CPAP or MAD
    NasopharynxAdenoidectomyAdenoid hypertrophy
    OropharynxTonsillectomy
    Barbed reposition pharyngoplasty (BRP)
    Expansion sphincter pharyngoplasty (ESP)
    Soft palate RFITT
    Tonsillar hypertrophy; in adults, mainly with other procedures
    Retropalatal obstruction
    Retropalatal obstruction
    Retropalatal obstruction in mild OSA
    Hyoid boneHyoidthyroidpexiaHypopharyngeal obstruction
    TongueTongue RFITT
    Transoral robotic surgery (TORS)
    Tongue suspension
    Moderate macroglossia and retrolingual obstruction, mainly in mild-to-moderate OSA, or as part of multilevel surgery
    Maxilla/mandibleMaxillomandibular advancement
    Maxillary expansion
    Mandibular deficiency, severe OSA with obstruction at multiple sites
    LarynxEpiglottopexyObstruction at the epiglottic level
    TracheaTracheostomyOnly in emergency situations; rarely performed when other treatments are not feasible in severe OSA
    MultisiteVariable combined proceduresObstruction at multiple sites in moderate-to-severe OSA

    CPAP: continuous positive airway pressure; MAD: mandibular advancement device; RFITT: radiofrequency interstitial thermotherapy.

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    Non-CPAP therapy for obstructive sleep apnoea
    Johan Verbraecken, Marijke Dieltjens, Sara Op de Beeck, Anneclaire Vroegop, Marc Braem, Olivier Vanderveken, Winfried Randerath
    Breathe Sep 2022, 18 (3) 220164; DOI: 10.1183/20734735.0164-2022

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    Non-CPAP therapy for obstructive sleep apnoea
    Johan Verbraecken, Marijke Dieltjens, Sara Op de Beeck, Anneclaire Vroegop, Marc Braem, Olivier Vanderveken, Winfried Randerath
    Breathe Sep 2022, 18 (3) 220164; DOI: 10.1183/20734735.0164-2022
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    • Article
      • Abstract
      • Abstract
      • Introduction
      • Lifestyle modification (behavioural therapy)
      • Oral appliances
      • Positional treatment
      • Surgery of the upper airway
      • Maxillomandibular surgery
      • Maxillary expansion
      • Bariatric surgery
      • Hypoglossal nerve stimulation
      • Drug treatment
      • Myofunctional therapy
      • Conclusions
      • Footnotes
      • References
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