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Idiopathic pulmonary fibrosis and lung cancer: future directions and challenges

Ahmad Abu Qubo, Jamil Numan, Juan Snijder, Maria Padilla, John H.M. Austin, Kathleen M. Capaccione, Monica Pernia, Jean Bustamante, Timothy O'Connor, Mary M. Salvatore
Breathe 2022 18: 220147; DOI: 10.1183/20734735.0147-2022
Ahmad Abu Qubo
1Department of Pathology, Faculty of Medicine, Hashemite University, Zarqa, Jordan
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  • ORCID record for Ahmad Abu Qubo
Jamil Numan
2Department of Radiology, Columbia University Medical Center, New York, NY, USA
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Juan Snijder
3Department of Pediatrics, Einstein Medical Center, Philadelphia, PA, USA
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Maria Padilla
4Department of Pulmonary Medicine, Mount Sinai, New York, NY, USA
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John H.M. Austin
2Department of Radiology, Columbia University Medical Center, New York, NY, USA
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Kathleen M. Capaccione
2Department of Radiology, Columbia University Medical Center, New York, NY, USA
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Monica Pernia
5Department of Medicine, Metropolitan Hospital, New York, NY, USA
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Jean Bustamante
6Department of Oncology, West Virginia University, Morgantown, WV, USA
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Timothy O'Connor
2Department of Radiology, Columbia University Medical Center, New York, NY, USA
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Mary M. Salvatore
2Department of Radiology, Columbia University Medical Center, New York, NY, USA
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  • For correspondence: ms5680@cumc.columbia.edu
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    FIGURE 1

    Evolution over 6 months of mucinous adenocarcinoma in a background of usual interstitial pneumonia on chest computed tomography. The cancer looks like consolidation, making early diagnosis challenging.

  • FIGURE 2
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    FIGURE 2

    a) An axial chest computed tomography (CT) image and b) a fused axial 2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)-CT image demonstrate peripheral squamous cell cancer occurring in a patient with a “probable usual interstitial pneumonia” pattern. There is low maximum standardised uptake value (SUVmax) in fibrotic lung parenchyma compared to tumour SUVmax of 12.5.

Tables

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  • TABLE 1

    Idiopathic pulmonary fibrosis (IPF) fulfils the five criteria set forth by the National Cancer Institute [45] and therefore qualifies as a precancerous condition

    Premalignant criteriaIPF
    Associated with an increased risk of cancerIPF has an increased risk of lung cancer
    When a precancer progresses to cancer, the resulting cancer arises from cells within the precancerLung cancer arises from cells within the precancer in IPF
    Differs from the normal tissue from which it arisesIPF differs from normal tissue from which it arises
    Differs from the cancer into which it developsIPF differs from the cancer into which it develops
    There is a method by which the precancer can be diagnosedIPF can be diagnosed by a combination of clinical, radiological and pathological features
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Vol 18 Issue 4 Table of Contents
Breathe: 18 (4)
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Idiopathic pulmonary fibrosis and lung cancer: future directions and challenges
Ahmad Abu Qubo, Jamil Numan, Juan Snijder, Maria Padilla, John H.M. Austin, Kathleen M. Capaccione, Monica Pernia, Jean Bustamante, Timothy O'Connor, Mary M. Salvatore
Breathe Dec 2022, 18 (4) 220147; DOI: 10.1183/20734735.0147-2022

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Idiopathic pulmonary fibrosis and lung cancer: future directions and challenges
Ahmad Abu Qubo, Jamil Numan, Juan Snijder, Maria Padilla, John H.M. Austin, Kathleen M. Capaccione, Monica Pernia, Jean Bustamante, Timothy O'Connor, Mary M. Salvatore
Breathe Dec 2022, 18 (4) 220147; DOI: 10.1183/20734735.0147-2022
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • Why does lung cancer occur in pulmonary fibrosis?
    • Is lung fibrosis a precancerous condition?
    • Difference between lung cancers in fibrotic versus non-fibrotic lung
    • Lung cancer screening in patients with pulmonary fibrosis
    • Treatment of lung cancer in patients with pulmonary fibrosis
    • Conclusion
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  • Interstitial and orphan lung disease
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