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An update on lung transplantation

Julia Fuller, Andrew J. Fisher
Breathe 2013 9: 188-200; DOI: 10.1183/20734735.001913
Julia Fuller
1Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne
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Andrew J. Fisher
1Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne
2Institute of Cellular Medicine, Newcastle University Medical School, Newcastle Upon Tyne, UK
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  • For correspondence: a.j.fisher@newcastle.ac.uk
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Abstract

Summary Over the last 25 years, lung transplantation has developed into a well-established treatment option for selected patients with very advanced lung disease.

In 2010, over a 12-month period, more than 3500 new lung transplant procedures were reported to the International Society of Heart and Lung Transplantation (ISHLT) Registry [1]. In 2011, 1830 lung transplants were performed in the USA [2]. In 2012, 690 were performed in the “Eurotransplant” region [3] and a further 170 within the UK [4]. New transplant programmes are now being established around Europe, increasing access to this life saving intervention and benefitting from sharing experience with more established centres. Although worldwide activity has increased year on year over the last decade (fig. 1), demand has also increased meaning the significant shortage of suitable donor lungs accounts for an unacceptably high waiting list mortality rate in many countries.

Figure 1
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Figure 1

The number of adult lung transplants reported to the ISHLT each year since 1985. Reproduced from [1] with permission from the publisher.

Clinical experience shared between transplant centres worldwide has helped refine the assessment process so that those added to a waiting list are those who are most likely to benefit. Furthermore, a meticulous approach to post-transplant management in the immediate post-operative period, in the early and long-term has contributed to continually improving long-term survival after lung transplantation.

Footnotes

  • Statement of Interest

    None declared.

  • ©ERS 2013
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An update on lung transplantation
Julia Fuller, Andrew J. Fisher
Breathe Mar 2013, 9 (3) 188-200; DOI: 10.1183/20734735.001913

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An update on lung transplantation
Julia Fuller, Andrew J. Fisher
Breathe Mar 2013, 9 (3) 188-200; DOI: 10.1183/20734735.001913
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  • Article
    • Abstract
    • What does lung transplant offer patients with advanced lung disease?
    • Who should be referred for lung transplant assessment and when?
    • What are the disease specific indications for referral for lung transplant assessment?
    • How are suitable donor lungs identified for patients on the waiting list?
    • What can be done to increase the availability of donor lungs for transplantation?
    • How do airway complications present after lung transplantation?
    • What are the common infections seen after lung transplantation?
    • How is immunosuppressive therapy used after lung transplant?
    • What are the long-term consequences of immunosuppressive therapy use?
    • How does lung transplant rejection present and what can be done for it?
    • What new on the horizon for lung transplantation?
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