RT Journal Article
SR Electronic
T1 Postgraduate Course ERS Glasgow 2004 Large cell carcinoma
JF Breathe
JO Breathe
FD European Respiratory Society
SP 315
OP 319
DO 10.1183/18106838.0104.315
VO 1
IS 4
A1 E. Brambilla
YR 2005
UL http://breathe.ersjournals.com/content/1/4/315.abstract
AB Educational aimsTo explain the importance of discriminating between different histological types of NSCLC.To explain the differences between large cell carcinoma (NOS) and their variants.To link precise histopathological class with prognosisSummary The histopathological classification of lung cancer was revised in 1999, and, in addition, descriptions of their phenotypic and genetic abnormalities were reported in 2004. Several changes have occurred that increased the clinical significance of lung cancer histopathological classification. These include the subclassification of large cell carcinoma, which was defined on a negative basis (on exclusion criteria), into variants which are defined on objective histopathological positive criteria that endowed them with a strong clinical significance.