TY - JOUR T1 - The adoption of nintedanib in systemic sclerosis: the SENSCIS study JF - Breathe JO - Breathe DO - 10.1183/20734735.0005-2020 VL - 16 IS - 2 SP - 200005 AU - Teresa Bruni AU - Francesco Varone Y1 - 2020/06/01 UR - http://breathe.ersjournals.com/content/16/2/200005.abstract N2 - We live in an era of respiratory medicine in which there is increasing awareness of interstitial lung diseases (ILDs). This is probably due to the publication of evidence-based guidelines [1, 2] and the discovery of newer drugs [3, 4]. These advances are particularly evident for idiopathic pulmonary fibrosis (IPF), which is to date the only fibrotic disease with specific pharmacologic-approved treatments. The burgeoning interest in pulmonary fibrosis has recently shifted its focus to the possibility of using therapeutic interventions available for IPF on other non-IPF ILDs, including pulmonary fibrosis secondary to systemic sclerosis (SSc). ILD represents one of the most relevant complications of SSc [5], but a standard treatment has yet to be achieved. Currently, the therapeutic management of SSc-ILD includes a “wait and see” approach in patients with a slow functional decay, and an immunosuppressive strategy (cyclophosphamide or mycophenolate) in patients with progressive ILD [6]. The Safety and Efficacy of Nintedanib in Systemic Sclerosis (SENSCIS) trial[7] explored the use of nintedanib, an intracellular inhibitor of tyrosine kinases currently approved for IPF, in scleroderma patients.Nintedanib shows a statistically significant effect on lung function decay in patients with ILD secondary to systemic sclerosis, but no effect on skin fibrosis and on health-related quality of life http://bit.ly/2vfJRj7 ER -