RT Journal Article
SR Electronic
T1 Idiopathic pulmonary fibrosis and lung cancer: future directions and challenges
JF Breathe
JO Breathe
FD European Respiratory Society
SP 220147
DO 10.1183/20734735.0147-2022
VO 18
IS 4
A1 Abu Qubo, Ahmad
A1 Numan, Jamil
A1 Snijder, Juan
A1 Padilla, Maria
A1 Austin, John H.M.
A1 Capaccione, Kathleen M.
A1 Pernia, Monica
A1 Bustamante, Jean
A1 O'Connor, Timothy
A1 Salvatore, Mary M.
YR 2022
UL http://breathe.ersjournals.com/content/18/4/220147.abstract
AB Idiopathic pulmonary fibrosis (IPF) is a progressive disease of pulmonary scarring. New treatments slow disease progression and allow pulmonary fibrosis patients to live longer. Persistent pulmonary fibrosis increases a patient's risk of developing lung cancer. Lung cancer in patients with IPF differs from cancers that develop in the non-fibrotic lung. Peripherally located adenocarcinoma is the most frequent cell type in smokers who develop lung cancer, while squamous cell carcinoma is the most frequent in pulmonary fibrosis. Increased fibroblast foci in IPF are associated with more aggressive cancer behaviour and shorter doubling times. Treatment of lung cancer in fibrosis is challenging because of the risk of inducing an exacerbation of fibrosis.In order to improve patient outcomes, modifications of current lung cancer screening guidelines in patients with pulmonary fibrosis will be necessary to avoid delays in treatment. 2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET) computed tomography (CT) imaging can help identify cancer earlier and more reliably than CT alone. Increased use of wedge resections, proton therapy and immunotherapy may increase survival by decreasing the risk of exacerbation, but further research will be necessary.Pulmonary fibrosis fulfils the criteria of precancer set forth by the US National Cancer Institute https://bit.ly/3QXIuK4