PT  - JOURNAL ARTICLE
AU  - Sancho, Jesus
AU  - Ferrer, Santos
TI  - How to increase noninvasive ventilation effectiveness in bulbar amyotrophic lateral sclerosis patients
AID  - 10.1183/20734735.0266-2022
DP  - 2023 Mar 01
TA  - Breathe
PG  - 220266
VI  - 19
IP  - 1
4099  - http://breathe.ersjournals.com/content/19/1/220266.short
4100  - http://breathe.ersjournals.com/content/19/1/220266.full
SO  - Breathe2023 Mar 01; 19
AB  - Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which the respiratory muscles are also affected, leading to respiratory failure. Bulbar impairment develops in almost all cases during the course of the disease, becoming severe in the late stages of disease. Noninvasive ventilation (NIV) has been shown to increase survival in ALS; however, severe bulbar dysfunction has a negative impact on NIV tolerance and effectiveness. Therefore, certain steps should be taken to improve NIV outcomes in these patients including optimal ventilatory parameters, adequate interface selection, effective respiratory secretion management and control of bulbar symptoms.In ALS patients, bulbar dysfunction has a negative impact on NIV tolerance and effectiveness. Optimal ventilatory parameters, adequate interface selection, effective respiratory secretion management and control of bulbar symptoms are required. https://bit.ly/3HKOGEi