PT - JOURNAL ARTICLE AU - Cordeiro, Ricardo AU - Nunes, André AU - Smith, Oliver AU - Renzoni, Elisabetta A. TI - Oxygen in interstitial lung diseases AID - 10.1183/20734735.0271-2022 DP - 2023 Mar 01 TA - Breathe PG - 220271 VI - 19 IP - 1 4099 - http://breathe.ersjournals.com/content/19/1/220271.short 4100 - http://breathe.ersjournals.com/content/19/1/220271.full SO - Breathe2023 Mar 01; 19 AB - Domiciliary oxygen is essential in the care of hypoxaemic interstitial lung disease (ILD) patients. Guidelines concur in advising prescription of long-term oxygen therapy (LTOT) for ILD patients with severe hypoxaemia at rest, in view of its beneficial impact on breathlessness/disability and extrapolating potential survival benefits seen in COPD patients. A less severe hypoxaemia threshold for initiation of LTOT is recommended for patients with pulmonary hypertension (PH)/right heart failure, requiring careful evaluation in all ILD patients. In light of evidence suggesting a link between nocturnal hypoxaemia, development of PH and poor survival, studies assessing the impact of nocturnal oxygen are urgently needed.Severe exertional hypoxaemia is frequent in ILD patients, with impact on exercise tolerance, quality of life and mortality. Ambulatory oxygen therapy (AOT) has been associated with improvement in breathlessness and quality of life in ILD patients with exertional hypoxaemia. However, given the paucity of evidence, not all current AOT guidelines are in agreement. Ongoing clinical trials will provide further useful data. Despite its beneficial effects, supplemental oxygen imposes burdens and challenges to patients. A key unmet area of need is the development of less cumbersome and more efficient oxygen delivery systems to reduce the negative impact of AOT on patients' lives.Oxygen therapy is of key importance in hypoxaemic ILD patients. Key unmet research areas include thresholds of hypoxaemia triggering intervention, the impact of nocturnal hypoxaemia treatment and development of user-friendly oxygen delivery systems. https://bit.ly/3YtmFXi