PT  - JOURNAL ARTICLE
AU  - Marine Savouré
AU  - Katie Eminson
AU  - Lucile Sese
AU  - Orianne Dumas
AU  - Yutong Samuel Cai
TI  - The exposome in respiratory diseases: multiple preventable risk factors from early life to adulthood
AID  - 10.1183/20734735.0034-2023
DP  - 2023 Jun 01
TA  - Breathe
PG  - 230034
VI  - 19
IP  - 2
4099  - http://breathe.ersjournals.com/content/19/2/230034.short
4100  - http://breathe.ersjournals.com/content/19/2/230034.full
SO  - Breathe2023 Jun 01; 19
AB  - The increasing global burden of respiratory diseases over the last decades raises questions about the impact of environmental factors during industrialisation and urbanisation. Although the knowledge of environmental epidemiology is growing, it is still unclear what the most critical exposure windows are for respiratory health. In addition, the relationships between different environmental exposures can be complex. The exposome approach investigating all non-genetic factors on health has been developed in recent years but has been little applied in respiratory health to date. This journal club article reviews three recent publications investigating the effects of environmental exposures, considered separately or in an exposome approach with different exposure windows, on respiratory health outcomes. These three studies highlight targets for action in primary and secondary prevention. Two studies, using data from the INMA and RHINESSA cohorts, support the regulation and reduction of phthalates and air pollution, respectively. Moreover, the exposome approach conducted in the NutriNet-Santé cohort emphasises that risk reduction must involve a multi-interventional approach targeting both specific early-life risk factors and promotion of a healthy lifestyle in adulthood. These three articles also present research perspectives in environmental epidemiology.The increasing global burden of respiratory diseases over recent decades raises questions about the lifelong impact of environmental factors during industrialisation and urbanisation. There is a clear need for action in primary and secondary prevention. https://bit.ly/3lv14zJ