Barriers to adherence
Treatment-related barriersClinician-related barriersPatient-related barriers
Complex treatment scheduleDifficulties in scheduling appointmentsPoor understanding of disease or treatment
Lack of an immediately discernible beneficial effectLack of empathy and interest from clinicianLack of trust in healthcare professionals
Adverse effectsRotating physiciansPsychological problems or psychiatric illness
Cost, reimbursement problemsPhysician provides information, but leaves little room for questions and concernsSocial issues (poverty, lack of healthcare insurance, lack of family (medication taking) routines)
Illness perceptions and medication beliefs hampering motivation to adhere