A summary of the procoagulant changes that occur in the blood system during pregnancy
| ↔ Factors II, V IX and protein C |
| ↑ Concentration of factors VII, VIII, X and vWF and pronounced increases in fibrinogen |
| ↓ Protein S |
| Plasminogen activator inhibitor type 1 levels are ↑ five-fold |
| PAI-2 produced by the placenta ↑ dramatically during third trimester |
| Markers of the thrombin generation such as prothrombin F1 and 2 and thrombin-antithrombin complexes are also increased |
| Do not return to baseline until more than 8 weeks postpartum, and begin at conception |