Table 2

Comparison of clinical and hemodynamic parameters in series of patients with COPD – PH with or without associated disease (left heart disease, thromboembolic disease, obesity hypoventilation or sleep apnoea), HFpEF – PH and PAH

COPD–PHHFpEF–PHPAH
Without associated diseaseWith associated disease
Subjects n11162020
Age years67 (63–68)61 (56–68)71.3±7.870.2±6.7
BMI kg m−226 (21–30)26 (22–33)31±6.828.2±3.2
Women %8070
mPAP mmHg48 (46–50)43 (42–49)50.2±7.150.2±9.5
PAWP mmHg6.0 (4.0–7.0)9.0 (4.0–18.0)22.8±4.49.6±3.1
RAP mmHg7.0 (5.0–9.0)5.0 (3.0–9.7)14.8±4.910.7±5.6
TPG mmHg27.5±4.840.5±8.8
DPG mmHg6.3±6.222.0±7.8
CI L min−1·m−22.3 (1.8–2.5)2.8 (1.9–3.8)2.5±0.52.3±0.3
TPR WU21.3 (17.6–26.6)14.9 (11.0–28.4)
PVR WU6.3±2.19.3±2.7
  • Data are expressed as mean±sd or median (interquartile range). BMI: body mass index; mPAP: mean pulmonary artery pressure; PAWP: pulmonary artery wedge pressure; RAP: right atrial pressure; TPG: transpulmonary gradient; DPG: diastolic pulmonary gradient; CI: cardiac index; TPR: total pulmonary resistance; PVR: pulmonary vascular resistance. Data from ref 40 and 41.