Table 1

Inclusion and exclusion criteria for SPACE registry participants

Inclusion criteria
 Age 6–17 years
 Diagnosis confirmed, evaluated and managed at a specialised centre for ≥6 months
  Wheeze heard by trained healthcare professional OR
  Self-reported wheeze in the past 12 months
 Spirometry evidence of asthma
  Bronchial obstruction with bronchodilator reversibility ≥12% OR
  Bronchial provocation test with ≥10% fall in FEV1
  High-dose inhaled corticosteroids (table 2) for ≥6 months + 
long-acting β-agonist/leukotriene modifier OR
  Systemic corticosteroids for ≥25% of the past 12 months
Exclusion criteria
 Symptoms are primarily due to the following conditions, which might mimic asthma
  Allergic bronchopulmonary aspergillosis
  Bronchiolitis obliterans
  Cystic fibrosis
  Primary ciliary dyskinesia
  Significant bronchiectasis (not related to asthma)
  Severe immunodeficiency/immunosuppression
  Central airway obstruction, or compression
  Congenital airway malformation (e.g. vascular ring)
  Foreign body
  Interstitial lung disease
  Other pulmonary surgery
  Carcinoid or other tumour
  Congenital heart disease
  Connective tissue disease
  Neuromuscular diseases

FEV1: forced expiratory volume in 1 s.