TableĀ 1

Nonrespiratory clinical manifestations of AATD

Organ(s)Clinical manifestationLife stage
LiverProlonged jaundice after birthInfant
HyperbilirubinaemiaInfant
Abnormal liver enzymesInfant/adult
CirrhosisAdult
Hepatocellular carcinomaAdult
Cholangiocellular carcinomaAdult
Adipose tissuePanniculitisYoung adult/adult
Small/medium-size vesselsGranulomatosis with polyangiitisAdult