Advice for severe and intermediate AATD
| Advice for severe AATD (homozygotes or compound heterozygotes) |
| Quit smoking |
| Avoid outdoor pollution and exposure to dust/irritants |
| Avoid alcohol and apply appropriate diet, in case of polymerogenic mutations |
| Test for AATD in first-degree relatives |
| Perform regular respiratory follow-up: lung function tests, lung imaging (if necessary) |
| Perform regular liver follow-up, in case of polymerogenic mutations: liver tests, abdominal ultrasounds, fibroscan |
| Give augmentation therapy, if necessary |
| Advice for intermediate AATD (heterozygotes) |
| Quit smoking |
| Avoid outdoor pollution and exposure to dust/irritants |
| Reduce alcohol and apply appropriate diet, in case of polymerogenic mutations |
| Perform regular respiratory follow-up: lung function tests, lung imaging (if necessary) |
| Perform regular liver follow-up, in case of polymerogenic mutations: liver tests, abdominal ultrasounds, fibroscan |