Table 1

The most important published studies assessing the efficacy of the e-nose for lung cancer

First author [ref.]YearLung cancer patients included/total study participantsType of noseResult
Philips [36]200895/180Gas chromatography and mass spectroscopySensitivity: 74%; specificity: 71%
Bajtarevic [35]2009220/661Gas chromatography and mass spectrometrySensitivity: 71; specificity: 100%
Dragonieri [39]200910/30CyranoseCross-validation value of 90% correct; sensitivity and specificity not reported
DAmico [40]201028/148Gas chromatography and mass spectroscopySensitivity: 85%; specificity: 100%
Gasparri [41]201670/146Gas sensor array composed of quartz microbalancesSensitivity: 81%; specificity: 91%
Rocco [12]201623/100PneumopipeSensitivity: 86%; specificity: 95%
De Vries [15]201835/604SpironoseSensitivity 80%; specificity 90%
Huang [28]201856/244CyranoseMultiple models
Support vector machine
Sensitivity: 83%; specificity: 86%
Tirzïte [26]2018252/475CyranoseTwo different models for smokers (sensitivity: 96%; specificity: 92%) and nonsmokers (sensitivity: 96%; specificity: 91%)
Kort [27]2018144/290AeonoseMultiple models used in the same population
Sensitivity: 94%; specificity: 33% (for the NSCLC model)
Van de Goor [42]201852/144AeonoseSensitivity: 83%; specificity: 84%