Summary of major RCTs in ARDS that produced contradicting results
| Study parameter | Initial trial | Year | Result | Subsequent trial | Year | Result |
| PP | Prone-Supine II [40] | 2009 | No impact on survival | PROSEVA [41] | 2013 | Improved survival |
| OLV | LOVS [42] | 2008 | No impact on survival | ART [43] | 2017 | Reduced survival |
| NMBA | ACURASYS [44] | 2010 | Improved survival | ROSE [45] | 2019 | No impact on survival |
| CS | NHLBI [46] | 2006 | No impact on survival | DEXA-ARDS [38] | 2020 | Improved survival |
PP: prone positioning; OLV: open-lung ventilation; NMBA: neuromuscular blocking agent; CS: corticosteroids.