Table 1

Potential management approaches for common symptoms in F-ILD

SymptomApproximate frequency in F-ILDManagement approaches
Dyspnoea54–98% [18]
  • Supplemental oxygen



    Pulmonary rehabilitation

    Multidisciplinary breathlessness service intervention

Fatigue8–29% [18]
  • Pulmonary rehabilitation

    Supplemental oxygen

Anxiety and depression14–50% [17, 18]
  • Antidepressants

    Cognitive behavioural therapy

Cough59–100% [18]
  • Treat exacerbating factors, e.g. proton pump inhibitors for gastro-oesophageal reflux


    Thalidomide (significant toxicity)

    Target cough reflex with gabapentin or amitriptyline

    Inhaled sodium cromoglycate (trial currently ongoing;, NCT03864328)