Table 1

Physiological effects of humidified high-flow therapy

Physiological effectImpact
Mucociliary clearance
  • Optimised respiratory epithelial function

  • Improved mucociliary transport in bench studies

Dead space washout
  • Reduced anatomical dead space

  • Carbon dioxide washout and oxygen reservoir

Improved pulmonary mechanics
  • Reduced work of breathing

  • Increased lung compliance

  • Improved gas exchange

  • Improved ventilation homogeneity