Summary of MCID values of physiological and patient-reported outcome measures in patients with IPF
| Variable | Author [ref.] | Time period weeks | Sample size (disease severity) | Anchors | Distribution method used | Improvement or deterioration | MCID value |
| FVC % pred | Du Bois [14] | 48 | 1156 (mild-to-moderate) | SF-2 Hospitalisation Death | Yes | Both | 2–6% |
| 6MWD m | Du Bois [18] | 48 | 826 (mild-to-moderate) | Hospitalisation Death | Yes | Both | 24–45# |
| Nathan [19] | 48 | 338 (mild-to-moderate) | Hospitalisation Death | Yes | Both | 21.7–37.0# | |
| Swigris [20] | 52 | 123 (mild-to-moderate) | FVC SGRQ | Yes | Both | 28 | |
| ISW m | Nolan [37] | 8 | 77 patients¶ | GRCQ | Yes | Improvement | 31–46# |
| Total SGRQ | Swigris [22] | 26 | 129 (mild-to-moderate) | FVC TDI | Yes | Both | 7 (5–10)+ |
| Swigris [23] | 52 | 1061 (mild-to-moderate) | FVC UCSD SOBQ PGI-C | Yes | Both | 4–5 | |
| SGRQ-I | Prior [24] | 52 | 124 (mild-to-moderate) | FVC DLCO 6MWD GRCS UCSD SOBQ SGRQ | No | Improvement | 3.9 |
| Deterioration | 4.9 | ||||||
| UCSD SOBQ | Swigris [25] | 24 | 180 (severe) | SGRQ-A | Yes | Both | 8 (5–11)+ |
| SF-36 | Swigris [22] | 26 | 129 (mild-to-moderate) | FVC | Yes | Both | 3 (MCS) |
| TDI | 3 (PCS) | ||||||
| Witt [27] | § | 258¶ | 6MWD FVC DLCO | Yes | Both | 6 (MCS) | |
| 5 (PCS) | |||||||
| KBILD | Prior [24] | 52 | 124 (mild-to-moderate) | FVC DLCO 6MWD GRCS UCSD SOBQ SGRQ | No | Improvement | 4.7 |
| Deterioration | 2.7 |
SGRQ-I: SGRQ for patients with IPF; SF-36: Short-Form Health Survey 36; SF-2: health transition question in SF-36 questionnaire; GRCQ: Global Rating of Change Questionnaire; TDI: Transition Dyspnea Index; PGI-C: Patient's Global Impression of Change; DLCO: diffusing capacity of the lung for carbon monoxide; GRCS: Global Rating of Change Scales; SGRQ-A: SGRQ activity domain; MCS: mental component score; PCS: physical component score. #: range; ¶: no set inclusion criteria based on disease severity; +: point estimate (range); §: no a priori follow-up time.