Changes in the haemodynamic definitions of PH
| WSPH/guideline document | PH | PAH | Pre-capillary PH | Post-capillary PH | Exercise PH |
| First WSPH (Geneva 1973) | mPAP >25 mmHg | Not defined | Not defined | Not defined | mPAP >30 mmHg |
| Second WSPH (Evian 1998) | No change | No change | No change | No change | No change |
| Third WSPH (Venice 2003) | No change | mPAP >25 mmHg + PAWP ≤15 mmHg + PVR >3 WU | No change | No change | No change |
| ESC PAH Guidelines 2004 [6] | No change | No change | No change | No change | No change |
| Fourth WSPH (Dana Point 2008) | mPAP ≥25 mmHg | mPAP ≥25 mmHg + PAWP ≤15 mmHg | No change | No change | Not defined |
| ESC/ERS PH Guidelines 2009 [9] | No change | No change | mPAP ≥25 mmHg + PAWP ≤15 mmHg | mPAP ≥25 mmHg + PAWP >15 mmHg (passive: TPG ≤12 mmHg, reactive: TPG >12 mmHg) | No change |
| Fifth WSPH (Nice 2013) | No change | mPAP ≥25 mmHg + PAWP ≤15 mmHg + PVR >3 WU | mPAP >25 mmHg + PAWP ≤15 mmHg + PVR >3 WU | mPAP ≥25 mmHg + PAWP >15 mmHg (isolated: DPG <7 mmHg, combined: DPG ≥7 mmHg) | No change |
| ESC/ERS PH Guidelines 2015 [15] | No change | No change | mPAP ≥25 mmHg + PAWP ≤15 mmHg | mPAP ≥25 mmHg + PAWP >15 mmHg (isolated: DPG <7 mmHg and/or PVR ≤3 WU, combined: DPG ≥7 mmHg and/or PVR >3 WU) | No change |
| Sixth WSPH (Nice 2018) | mPAP >20 mmHg | mPAP >20 mmHg + PAWP ≤15 mmHg + PVR ≥3 WU | mPAP >20 mmHg + PAWP ≤15 mmHg + PVR ≥3 WU | mPAP >20 mmHg + PAWP >15 mmHg (isolated: PVR <3 WU, combined: PVR ≥3 WU) | No change |