Current medications in use for TB treatment and their notable side-effects

DrugNotable side-effects
Rifampicin (RIF)Hepatotoxicity, nausea, dyspepsia, abdominal pain, rash, CYP450 interactions
Isoniazid (INH)Hepatotoxicity, peripheral neuropathy#, optic neuritis, CYP450 interactions
Pyrazinamide (PZA)GI disturbance, hepatotoxicity, gout
Ethambutol (EMB)Optic neuropathy
Levofloxacin (LFX)/Moxifloxacin (MFX)QT prolongation, tendonitis, hypoglycaemia, psychiatric disturbance
Bedaquiline (BDQ)QT prolongation, CYP450 interactions
Linezolid (LZD)Myelosuppression, dysglycaemia, peripheral neuropathy#, optic neuropathy
Clofazimine (CFZ)Hepatotoxicity, GI disturbance, neurological disturbance, QT prolongation, altered skin pigmentation
Cycloserine (CYS)Psychiatric disturbance, peripheral neuropathy
Delamanid (DLM)QT prolongation, CYP450 interactions
Aminoglycosides (AMK,CAP, STR)Nephrotoxicity, ototoxicity
Ethionamide (ETH)/Prothionamide (Pro)Psychiatric disturbance, peripheral neuropathy, hepatotoxicity, hypothyroidism, dysglycaemia
p-Aminosalicylic acid (PAS)Hepatotoxicity, dysglycaemia, hypothyroidism
Amoxicillin–Clavulanate with Meropenem or Imipenem–CilastatinDiarrhoea, candidiasis

#: given with pyridoxine prophylaxis to ameliorate risk; : beta-lactams must be given with Clavulanate for success in TB treatment; however, the only available preparations include Amoxicillin. Information from [50].